Shakespeare's Birthplace and Exhibition of Shakespeare's World. Welcome to the world-famous house where William Shakespeare was born in 1564 and where he grew up. The property(房产) remained in the ownership of Shakespeare's family until 1806. The House has welcomed visitors travelling from all over the world，for over 250 years.

◆Enter through the Visitors' Centre and see the highly-praised exhibition Shakespeare's World, a lively and full introduction to the life and work of Shakespeare.

◆Stand in the rooms where Shakespeare grew up.

◆Discover examples of furniture and needlework from Shakespeare's period.

◆Enjoy the traditional(传统的) English garden, planted with trees and flowers mentioned in the poet's works.

    The Birthplace is within easy walking distance of all the car parks shown on the map；nearest is Windsor Street(3 minutes' walk)．

The House may present difficulties but the Visitors' Centre, its exhibition, and the garden are accessible(可进入的) to wheelchair users.

    The Shakespeare Coffee House(opposite the Birthplace).

How to Build Healthy Interpersonal Relationship

    Human beings are social creatures and thrive(茁壮成长) in relationships with others. A healthy part to be a well-rounded, happy individual is engaging in healthy relationships with others.These friendships can provide safe environments in which individuals can thrive and help promote general well-being. {#blank#}1{#/blank#}

1)．Know your worth.

    One of the first steps in building healthy interpersonal relationships is understanding one's value. When an individual is aware of and treasures what he or she has, the building of relationships can be founded on that knowledge. {#blank#}2{#/blank#} Everyone has talents. When this worth is discovered, a person can then make use of these skills in approaching interpersonal relationships. If someone is a good listener, showing how to develop this skill can attract relationships with individuals who have a need for this talent.

2)．Recognize the value of others.

    {#blank#}3{#/blank#} In a healthy interpersonal relationships, both parties should be respected and feel as if they are valued in the friendship. When contributions to the relationship become one－sided, the relationship will move from healthy to unhealthy.

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    Another way to build healthy relationships is to make friends with someone who shares the same value systems and lifestyles. Knowing that a friend will not request something from an individual will help to foster trust in the relationship. {#blank#}5{#/blank#} The relationship can grow on this familiarity. Trust can also develop from these similarities and go a long way in fostering a healthy friendship.

A. Everyone has worth.

B. Be true to yourself.

C. Seek out individuals with similar value systems.

D. A healthy interpersonal relationship cannot be built on dishonesty.

E. Also, having the same lifestyle can provide a link of familiarity.

F. Here are some tips to build healthy interpersonal relationships.

G. Along with understanding one's worth is recognizing and understanding the worth of others.

    You may think that sailing is a difficult sport, but it is really not hard to learn. You do not need to be strong. But you need to be quick. And you need to understand a few basic rules about the wind.

    First, you must ask yourself, “Where is the wind coming from? Is it coming from ahead or behind or from the side?” You must think about this all the time on the boat. The wind direction tells you what to do with the sail.

    Let's start with the wind blowing from the behind. This means the wind and the boat are going in the same direction. Then you must always keep the sail outside the boat. It should be at a 90° angle to the boat. Then it will catch the wind best.

    If the wind is blowing from the side, it is blowing across the boat. In this case, you must keep the sail half way outside the boat. It should be at a 45°angle to the boat. It needs to be out far enough to catch the wind, but it shouldn't flap(摆动). It shouldn't look like on a flagpole. If it is flapping, it is probably out too far, and the boat will slow down.

    Sailing into the wind is not possible. If you try, the sail will flap and the boat will stop. You may want to go in that direction. It is possible, but you can't go in a straight line. You must go first in one direction and then in another. This is called tacking. When you're tacking, you must always keep the sail inside the boat.

    Greece's finance minister says his country's financial situation is “terribly urgent” and the crisis could come to a head in a couple of weeks. Yanis Varoufakis gave the warning after eurozone finance ministers met in Brussels to discuss the final €7.2bn tranche(援助资金) of Greece's €240bn EU/IMF bailout(紧急援助).

    Ministers said Greece had made “progress” but more work was needed.

The Greek government is struggling to meet its payment obligations（责任）.Earlier, Greece began the transfer of €750m (£544m, $834m) in debt interest to the International Monetary Fund - a day ahead of a payment deadline.

    “The liquidity（资产流动性） issue is a terribly urgent issue. It's common knowledge, let's not beat around the bush,” Mr Varoufakis told reporters in Brussels. “From the perspective of timing, we are talking about the next couple of weeks.”

    Greece has until the end of June to reach a reform deal with its international creditors. Its finances are running so low that it has had to ask public bodies for help. The crisis has raised the prospect that Greece might default（违约） on its debts and leave the euro.

    In a statement, the eurozone finance ministers said they “welcomed the progress that has been achieved so far” in the negotiations,” but added: “We acknowledged that more time and effort are needed to bridge the gaps on the remaining open issues.” Eurogroup chairman Jeroen Dijsselbloem said there had to be a full deal on the bailout（紧急财务援助） before Greece received any further payments. “There are time constraints(限制；约束) and liquidity constraints and hopefully we will reach an agreement before time runs out and before money runs out.” he said.

    There had been fears that Greece would default on its IMF debt repayment due on Tuesday. However, a Greek finance ministry official was quoted as saying that the order for repayment had been executed（实施） on Monday. Almost €1bn has been handed over to the IMF in interest payments since the start of May.

    It is unclear how the government came up with the funds, but the mayor of Greece's second city Thessaloniki revealed last week that he had handed over cash reserves in response to an appeal for money.

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

Plastic-Eating Worms

    Humans produce more than 300 million tons of plastic every year. Almost half of that winds up in landfills(垃圾填埋场) and up to 12 million tons pollute the oceans. So far there is no effective way to get rid of it, but a new study suggests an answer may lie in the stomachs of some hungry worms.

    Researchers in Spain and England recently found that the worms of the greater wax moth can break down polyethylene, which accounts for 40% of plastics. The team left 100 wax worms on a commercial polyethylene shopping bag for 12 hours, and the worms consumed and broke down about 92 milligrams, or almost 3% of it. To confirm that the worms' chewing alone was not responsible for the polyethylene breakdown, the researchers made some worms into paste(糊状物)and applied it to plastic films. 14 hours later the films had lost 13% of their mass — apparently broken down by enzymes (酶) from the worms' stomachs. Their findings were published in Cun ent Biology in 2017.

    Federica Bcrtocchini, co-author of the study, says the worms' ability to break down their everyday food — beeswax — also allows them to break down plastic. "Wax is a complex mixture, but the basic bond in polyethylene, the carbon-carbon bond, is there as well," she explains, "The wax worm evolved a method or system to break this bond."

    Jennifer DeBruyn, a microbiologist at the University of Tennessee, who was not involved in the study, says it is not surprising that such worms can break down polyethylene. But compared with previous studies, she finds the speed of breaking down in this one exciting. The next step, DeBruyn says, will be to identify the cause of the breakdown. Is it an enzyme produced by the worm itself or by its gut microbes(肠道微生物)?

    Bertocchini agrees and hopes her team's findings might one day help employ the enzyme to break down plastics in landfills. But she expects using the chemical in some kind of industrial process — not simply "millions of worms thrown on top of the plastic."