I was never very neat, while my roommate Kate was extremely organized. Each of her objects had its place, but mine always hid somewhere. She even labeled（贴标签）everything. I always looked for everything. Over time, Kate got neater and I got messier. She would push my dirty clothing over, and I would lay my books on her tidy desk. We both got tired of each other.

    War broke out one evening. Kate came into the room. Soon, I heard her screaming. “Take your shoes away! Why under my bed!” Deafened, I saw my shoes flying at me. I jumped to my feet and started yelling. She yelled back louder.

    The room was filled with anger. We could not have stayed together for a single minute but for a phone call. Kate answered it. From her end of the conversation, I could tell right away her grandma was seriously ill. When she hung up, she quickly crawled（爬）under her covers, sobbing.

    Obviously, that was not something she should not go through alone. All of a sudden, a warm feeling of sympathy rose up in my heart.

    Slowly, I collected the pencils, took back the books, made my bed, cleaned the socks and swept the floor, even on her side. I got so into my work that I even didn't notice Kate had sat up. She was watching, her tears dried and her expression one of disbelief. Then, she reached out her hands to grasp mine. I looked up into her eyes. She smiled at me, “Thanks.”

    Kate and I stayed roommates for the rest of the year. We didn't always agree, but we learned the key to living together: giving in, cleaning up and holding on.

    We would like to wish all our readers a wonderful winter break. Our January magazine is now in the shops and available digitally. We're looking forward to sharing more adventures and discoveries with you in 2018, including:

    At a crossroads in the Atlantic

    As the population of Ascension Island rises up to mark the 200th anniversary of British rule, Fred Pearce wonders what the future might have in store for this strange part of land.

    Photo story: On the road again

    A selection of images from an exhibition opening this month at the Royal Geographical Society go hand in hand with M. Aurel Stein's early 20th century photo graphs of the Silk Road.

    Dossier: Going underground

    Mark Rowe discusses the role that carbon storage can play in the global effort to reduce carbon dioxide emission (排放).

    Net loss

    Kit Gillet reports from the Gulf of Thailand, whose fisheries (渔场) have been almost destroyed by the commercialization of the Thai fishing industry.

    And don't forget… a round-up of the latest geographical and climate science news; a hot spot focus on Turkey; advice on taking photographs in Antarctica; an interview with Lucien Castaing-Taylor, professor of visual arts at Harvard; plus lots, lots more.

    Buy your copy now, click here and save up to 35% or call+44 (0)1635 588 496.Geographical is also available in WHSmith and many independent news agents.

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

    The United States Postal Service(LISPS)is offering a way to people who are interested in seeing tomorrow's mail today. The postal service will send consumers images(图像)of their letters, magazines and other mail before they arrive. The new service is called Informed Delivery. It is an attempt to remain competitive in an ever—changing world.

    Postal service officials say the increased use of email, digital messaging services and social media has made it difficult to stay relevant. David Rupert is a media relations specialist who spoke about the competition the agency now faces. Whether you turn on a television or your computer, or people come to your door with different products and services, all of those are competing for consumers' time and energy, he said.

    Interested users are first required to sign up for Informed Delivery. Once registered, the consumer receives a daily email with virtual(虚拟)images of letters or other things to be delivered. The US Postal Service says it can especially help those who have a mailbox at their local post office, so they know when to get their mail：

    Another postal offering is a service that seeks to make advertising-related mail-often called junk mail—more fun. The service uses virtual and augmented reality(虚拟现实和增强现实)to let consumers interact with their junk mail. Many companies put special coding on their advertising, which can give users an interactive experience. Some companies even put virtual reality eyeglasses in the mail to make their ads come to life. Consumers have mixed reactions to virtual and augmented reality advertising. “You can find some good things within junk mail. It is a good idea. We'll see how it works, ”Postal service user Victor Teah said. But Jocelyn Coatney doesn't think it would change her mind about junk mail. “For some, that might be fun. But for me, it would be useless, ”she said.

    It was rainy, and I had no desire to drive up the winding mountain road to my daughter Carolyn's house. But she had insisted that I come to see something at the top of the mountain.

    So here I was, reluctantly making the two-hour journey through fog that hung like veils. By the time I saw how thick it was near the summit, I'd gone too far to turn back.

    Nothing could be worth this, I thought as I inched along the dangerous highway.

    "I'll stay for lunch, but I' m heading back down as soon as the fog lifts," I announced when I arrived.

    "But I need you to drive me to the garage to pick up my car," Carolyn said, "Could we at least do that?"

    "How far is it?" I asked.

    "About three minutes," she said, "I'll drive—I'm used to it."

    After ten minutes on the mountain road, I looked at her anxiously. "I thought you said three minutes."

    She grinned. "This is a detour."

    Turning down a narrow track, we parked the car and got out. We walked along a path that was thick with old pine needles. Huge black-green evergreens towered over us. Gradually, the peace and silence of the place began to fill my mind.

    Then we turned a comer and stopped—and I gasped in amazement.

    From the top of the mountain, sloping for several acres across the mountain side and valleys, were rivers of flowers in numerous colors. It looked as though the sun had tipped over and spilled gold down the mountainside.

    A series of questions filled my mind. Who created such beauty? Why? How?

    As we approached the home that stood in the center of the property, we saw a sign that read: "Answers to the Questions I Know You Are Asking."

    The first answer was: "One Woman—Two Hands, Two Feet, and Very Little Brain." The second was: "One at a Time." The third: "Started in 1958."

    As we drove home, I was so moved by what we had seen. I could scarcely speak. "She changed the world." I finally said, "one bulb (球茎) at a time. She started almost 40 years ago, probably just the beginning of an idea, but she kept at it."

    The wonder of it would not let me go. "Imagine," I said, "if I'd had a vision and worked at it, just a little bit every day, what might I have accomplished?"

    Carolyn looked at me sideways, smiling. "Start tomorrow," she said. "Better yet, start today."

    We interviewed two people, one who went from the country to the city and one who did the opposite.

    Janet Lincoln is a salesgirl who moved to St. Louis five years ago. Here's what Janet told us:

    "Five years ago I used to live in a small town called Lemon Falls. I grew up and went to high school there. After I graduated I worked in a supermarket. Lemon Falls had a population of about 800 people, and I knew every single one of them. They all knew everything about me, too. You couldn't do anything without everyone in town knowing about it. The first chance I got I moved to St. Louis and I love it. I don't know as many people now as I used to, but that's OK.I have a few good friends, and I see them when I want to. I kind of like being anonymous. I'd never go back to Lemon Falls."

    Troy Henson had the opposite experience. He and his wife, Darla, and their two children moved from St. Louis to Bloomfield three years ago. Here's what Troy told us:

    "The best thing we ever did was get out of St. Louis. Don't get me wrong; St. Louis is as good a place as any other city, I suppose—if you like cities, that is. We don't. Both Darla and I grew up in St. Louis. We met at college and got married. Then the kids came along and life got difficult. We didn't know any of our neighbors. We both had good jobs, but it always seemed like there was never enough money. That all changed when we moved to Bloomfield. I don't make as much money as I used to, but then we don't have as many expenses as we did. We know our neighbors. Life is good. We'd never leave Bloomfield."