Nowadays people are putting our water supply in danger, because they use too much water or throw rubbish into the river. You may wonder how paving(铺砌) a road can lead to less usable fresh water. A major part of thewaterweuse every day is groundwater. Groundwater does not come from lakes or rivers. It comes from underground. The more roads and parking lots we pave，the less water can flow into the ground to become groundwater.

    Human activity is not responsible for all water shortages(短缺). Drier climates are of course more likely to have droughts(干旱) than areas with morerainfall，but in any case, good management can help to make sure there is enough water to meet our basic needs.

    Thinking about the way we use water every day can make a big difference，too. In the United States，a family of four can use 1.5 tons of water a day! This shows how much we depend on water to live，but there's a lot we can do to lower the number.

    You can take steps to save water in your home. To start with，use the same glass for your drinking water all day. Wash it only once a day. Run your dishwasher (洗碗机)only when it is full. Help your parents fix any leaks in your home. You can even help to keep our water supply clean by recycling batteries instead of throwing them away.

根据短文内容，选择最佳答案，并将选定答案的字母标号填在题前括号内。

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

    One of the most important aspects of an image is color. People are very sensitive to color, and different colors have different on people.

    In general, red is an exciting color, which creates an image of action, energy danger. Red is also the most frequently used color in flags. Eighty percent of the world's flags contain red. A study in Germany showed that football teams wearing red are more successful. Blue is a very calm color. Business executives usually wear dark blue suits. Blue is also a peaceful color. The flag of the United Nations is light blue. Yellow is associated with openness and freedom. Green is a very relaxing color. Surgeons nowadays wear green, because it's less tiring than white. Black creates an image of power and authority. It can also be a very threatening color. Gangsters and vampires often wear black, white is a pure and strong color. This is one reason why doctors wear white coats. We trust them more. Grey is a very anonymouscolor. People wearing grey don't want other people to notice them. Brown is the opposite of black. It's warm and friendly, while black is threatening

    Important facts about ELIQUIS® (apixaban)

    This is a summary of important information that you need to know about ELIQUIS. Keep this document in a safe place, so you can refer to it before and during your treatment.

    Look out for the following signs as you read:

Do not stop taking ELIQUIS without talking to the doctor who prescribed (开处方) it to you.

    Talk to your healthcare team before any medical procedures. ELIQUIS may need to be stopped before surgery, or a medical or dental procedure. Your doctor will tell you when you should stop taking ELIQUIS and when you may start taking it again. If you have to stop taking ELIQUIS, your doctor may prescribe another medicine to help prevent a blood clot from forming.

    What is the possible serious side effect of ELIQUIS?

    ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting. While taking ELIQUIS, you may hurt more easily and it may take longer than usual for any bleeding to stop.

    Call your doctor or get medical help right away if you have any symptoms of bleeding when taking ELIQUIS.

    Who should not take ELIQUIS?

    ELIQUIS is not for patients who:

    Have artificial heart valves (瓣膜). Currently have certain types of abnormal bleeding. Have had a serious allergic (过敏的) reaction to ELIQUIS.

    What should I discuss with my healthcare team before starting ELIQUIS?

    Talk to your healthcare team about the following:

    Liver problems any other medical conditions if you have ever had bleeding problems.

    Tell your doctor if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed. You and your doctor should decide whether you will take ELIQUIS or breastfeed. You should not do both.

    Tell your healthcare team about all of the medicines you are taking.

    I have learned something about myself since I moved from Long Island to Florida three years ago. Even though I own a home in Port St. Lucie just minutes from the ocean, an uncontrollable urge wells up to return to Long Island even as others make their way south. I guess I am a snowbird stuck in reverse. Instead of enjoying Florida's mild winters, I willingly endure the severe weather on Long Island, the place I called home for 65 years.

    I'm like a migratory bird that has lost its sense of timing and direction, my wings flapping against season.

    So what makes me fly against the tide of snowbirds? The answer has a lot to do with my reluctance to give up the things that define who I am. Once I hear that the temperature on Long Island has dipped into the range of 40 to 50 degrees, I begin to long for the sight and crackling sound of a wood fire. I also long for the bright display o£ colors — first in the fall trees, and then in the limits around homes and at Rockefeller Center. Floridians decorate too, but can't create the special feel of a New England winter.

    I suppose the biggest reason why I return is to celebrate the holidays with people I haven't seen in months. What could be better than sitting with family and friends for a Thanksgiving turkey dinner, or watching neighbors' children excitedly open gifts on Christmas? Even the first snowfall seems special. I especially enjoy seeing a bright red bird settling on a snow-covered branch (My wife and I spend winters at a retirement community in Ridge, and I'm grateful that I don't have to shovel.）

    While these simple pleasures are not unique to Long Island, they are some of the reasons why I come back. Who says you can't go home?

    Kompong Phhluk Private Tour

    Depart the city for an unspoiled floating community called Kompong Phhluk which is well-known for its stilted-house (吊脚楼) villages and flooded forest.

    Stop on the way for the Rolous Market tour. This is a great chance for you to take the photos of locals selling vegetables, different fish species and other local produce.

    After this market tour we'll all have a boat trip to the floating community of Kompong Phhluk, visit an island pagoda, school and houses standing on 8 or 10m high stilts, fish farms and learn about the village life.

    Stop and have lunch in a family's house before getting into a row boat and venturing into the flooded forest, the habitat to some famous water-bird species.

    Eventually we jump back into the big boat and set off for the largest fresh water lake in SE Asia, Tonle Sap.

    Tour Details

    Departs 8.30am

    Returns around 2pm

    A picnic lunch with sandwiches and drinks is provided. We cannot provide local food from the area due to poor sanitation (卫生设备), lack of hygiene standards and refrigeration.

    No passes required

    Rates

    These rates are based on an English speaking guide.

    Rates include all transport, water and a picnic lunch.

·    Children 11 years and under are 50%.

    Children 4 years and below are free.

    If your group is larger than 5 people please email us for the best rate.

    Number of People Price Per Person

    1 Person  $65

    2 People  $45

    3 People  $40

    4 People  $35

    5 People  $32

    What to Wear

    Please be mindful of your clothing and try to avoid anything too revealing

    We strongly recommend a sunglasses, hat and sunscreen.

    General Information

    This is a poor rural village, please be mindful of the environment.

    Please do not hand things out to villagers, for this leads to creating a begging cycle and can create jealousy.

    We recommend heading to the toilet before you go on this trip as facilities (设施) are very basic.