题型:阅读理解 题类:模拟题 难易度:普通
北京市东城区2021届高三下学期英语一模试卷
Accines (疫苗) may soon make their first film appearance. Led by expert Maria A. Croyle, researchers have developed a thin sheet that preserves vaccines for long periods without refrigeration. This means the carefully cooled small bottles now used to ship vaccines could potentially be replaced by lightweight films that can be mailed in an envelope and stored on a shelf.
Croyle's laboratory began developing the technology in 2007. Inspired by amber's ability to preserve the DNA of insects, the researchers set out to create their own version of the substance by mixing "a lot of sugar and a little bit of salt, much like hard candy," Croyle explains. The vaccine-containing film is administered by mouth—sweet news for many who dislike needles.
The film is tailored to suit each specific vaccine candidate and provide a protective coating. "We've learned over time that the key to really stabilizing whatever the film holds is to have it intermixed with all the components," Croyle says, adding that the process is quick and uses affordable, standard equipment. "We really wanted to come up with something that would be transferable to developing countries."
Immunization(免疫) programs depend heavily on keeping vaccines cold(2℃-8℃) as they are transported, sometimes over thousands of kilometers to far-away locations. Delivery can be difficult and costly, and transport disruptions can cause the vaccines to be ineffective.
But this new product can store live viruses, bacteria and antibodies for several months at 20℃. In a paper published in Science Advances, the scientists show that the live viruses in one vaccine were preserved in the film even after 36 months. They also find that a flu vaccine suspended in their film compares favourably with a traditional flu shot(流感预防针). "The study demonstrates early proof of concept for an exciting platform for vaccine product development," says Lisa Rohan, a pharmacologist, who was not involved in the study. She also notes that each vaccine type would need a custom formulation(配方) for future stages of development.
Finding partners to mass-produce for clinical trials is the researchers' most pressing problem, Croyle says. They are also exploring packaging methods to keep their films stable up to 40℃.
Size is a major advantage—a letter-sized sheet of the film can carry more than 500 doses(剂) of vaccine, about 1⁄900 the weight of the same amount of traditional doses. By making it easier and cheaper to ship and preserve vaccines efficiently, Croyle says, the technology could vastly improve immunization rates the world over, particularly in middle- to low- income countries.
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