This year's flu season is pretty scary. To try to minimize the effects, public officials are still urging anyone who hasn't yet gotten their flu shot to get one as soon as possible. However, even if every single person got a shot in the arm, the vaccine(疫苗)— with its excellent 36 percent effectiveness—would not prevent everyone from getting infected with the annoying virus. Knowledge is power, so here's what goes on in your body when you come down with the flu.

    The influenza virus primarily attacks your nose, throat, and the tubes that lead to your lungs. But the flu is so much more than that. Your muscles ache, your head hurts, and your appetite goes down, among other things. To our surprise, almost all of these symptoms have less to do with the virus itself than with your immune(免疫的)response to them. Unfortunately, the very defense you have in place to ge rid of the flu is the reason you feel so painful when you recover.

    The virus usually enters through your mouth, typically by way of your hands. But it takes a few days for symptoms to set in. While this process might cause some harm to your nose and throat, it's nothing major, and nothing like the symptoms that typically accompany a bad or even mild case of the flu.

    The real fun starts when your immune system begins to fight. Your immune system comes in two parts: the innate system and the adaptive. The innate immune system is essentially an all-purpose tool. As soon as your body senses the presence of any injury or invader (入侵者), the innate immune system launches into action by producing tiny proteins called cytokines and chemokines. The cytokines reproduce almost immediately and start to attack the virus. This increase in immune cells creates an serious inflammation(炎症) throughout the body. But the worst is still to come. Meanwhile, the chemokines work with the adaptive immune system to help create T cells. These cells are a special type of white blood cell that works in a much more specific way: They find the influenza virus, identify what's special about it, and create something unique on their surface that finds and destroys similar invaders.

    She almost did not run. Christine Williams admits that now. She could barely put one foot after another following the wake(守灵) for her sister, who had died in an automobile accident. But she did run. With the cheers of friends and strangers reaching her heart, Williams set a C.W. Post record in Boston. Now she will run again, in the national Division II cross-country championships in Evansville, Ind. She wanted to be sure she was doing the right thing by running. She was the middle of three sisters, between Kerry, who is 25, and Jennifer, who was 18.

    Just going through any motions was hard enough, but Christine Williams wanted to know if she should put on her uniform and her shoes and run through the woods on an autumn afternoon, in the awful gaping time between her sister's wake and her funeral. “I kind of got upset beforehand.”Williams admitted. Not a chatterbox under normal conditions, she now holds herself the best way she can, the fewer words the better. She almost walked away from the start line. But her friend Angela Toscano, who had flown up to Boston with her, directly from the wake, was standing near the line and talked her through it. “She said my sister would have wanted me to run.” Christine said. And that was enough to get her started.

    The accident happened just after midnight on Nov, 4. Four young women were driving in an unfamiliar area of Long Island in Eastport, N.Y., when one of them apparently ran a yield sign, and the car was hit by another vehicle. Heather Brownrigg and Jennifer Williams died, and their friends April Brown and Kaci Moran were treated at a hospital and released.

    The crash made the papers. April Brown was charged with drunken driving and driving without a license.

    The wake began on Nov. 6. The next day Christine was to run with the Post cross-country team at the regional meet. Rich Degnan, the Post coach, and Post officials offered a car service and tickets on the last flight to Boston for Christine and Toscano. When they arrived at the hotel, the entire team was waiting up for her.

    Everybody knew about it at the regional meet. Degnan had to arrange for the flexibility of an alternate, just in case Christine could not go. Several times during the race, Christine felt she could not continue. But then she heard her friends and all those other people, those strangers from other colleges, calling her name. She thought about Jennifer. And she ran. She finished fourth in 22 minutes 58 seconds, breaking the Post record for the 6-kilometer distance by 15 seconds. And although the Post team didn't qualify for the nationals, Christine did.

    As anyone who freelances (做自由职业) knows, there are lots of advantages of working at home alone. But there are drawbacks too, like the potential loneliness. No wonder co-working spaces are becoming so popular, they permit self-employed individuals to feel like they are part of all office environment, while making them get some work done too. But renting a co-working space does cost money.

    Now a Swedish project is aiming to change that by turning people's under-used homes into temporary co-working spaces, available to freelancers for free. Hoffice was started by freelancers Christofer Gradin Franzen and Johline Zandra about a year ago in Stockholm when they invited a few people into their home office to work together. It was a great success, and the project has since spread to a number of cities in Europe, North and South America, Australia, India and Japan. Anyone can sign up and offer their home space as a free co-working space, or go find a Hoffice near them.

    On a Hoffice day, everyone arrives and starts work at a certain hour. After 45 minutes，everyone gets up to take a break, stretch, do qigong or yoga for 10 to 15 minutes. Afterwards， people can gather around again, and re-state their intentions and goals for the rest of the work day, as a way to motivate each other. Meals can be eaten together at a certain hour, potluck-style (家常饭) or by bringing their own lunch.

    This process creates an encouraging and supportive work environment. As some freelancers describe, "By working at Hoffice, we give ourselves and each other the gift to spend our days in a social working environment, where we are extremely productive without ignoring our other human needs. We also make sure to give ourselves and each other what we need to feel calm, happy, inspired and creative during the working day."

    So Hoffice is not just about sharing space; it's also about a free exchange of ideas. And perhaps the best thing is that Hoffices are free to use.

    "Be proud of what you do"(对你所做的感到骄傲), my father always told me, "whether you are a boss （老板）or a cleaner", When I was 15, I got a summer job in a hospital, I was told that my duties would include sweeping floors. I smiled and remembered Dad's words. Even though my job was the lowest, it made me feel excited. I saw it as a challenge because it was my first job. I learned to be on time and tried to do everything well. In return(作为回报), I was treated with respect（尊重） by doctors, nurses and patients. Each morning I imagined that the dirty dishes would make patients more sick if I were not there to wash them clean. After breakfast was done, I started sweeping the floors of all patient rooms and cleaning toilets. Though I was tired, I wanted the job to be done well, people would say, "That young boy really does a good job." That gave me a pride. Working in the hospital taught me that being proud of one's job is important. It does not matter whether the job is sweeping floors or managing a large business. Though every job I have ever had, my father's words have always stayed with me, I have swept floors, and I have been a manager（经理）. I think Dad would be proud of me!

    From 100 years of Bauhaus to 350 years since Rembrandt's death, a host of landmark art events and exhibitions are open around Europe this year.

    John Ruskin 200th England

    This year is also the bicentenary (200周年纪念) of the birth of John Ruskin, the art critic, writer and reformer. There are exhibitions throughout the year at Brantwood, his former home in Cumbria, on topics from his clothes to his interest in geology and his legacy in Japan. On Ruskin's birthday, 8 February, there is a free public lecture on his love of trees at Oxford University Museum of Natural History and an evening of readings and music at the Royal Academy, London.

    Rembrandt 350th The Netherlands

    It is 350 years since the death of Rembrandt van Rijn. There is a year-long programme of events in nine Dutch cities, focusing on Rembrandt and the Dutch golden age. In Amsterdam, the Rijks Museum (15 Feb-10 June) will display all of its 22 paintings, 60 drawings and 300 engravings – the biggest Rembrandt collection ever seen in a single exhibition.

    Bauhaus 100th Germany

    Germany is celebrating the centenary of Bauhaus, the revolutionary art school founded by Walter Gropius in 1919. The opening festival is already under way at the Berlin Academy of Arts, with a programme of concerts, plays and virtual reality installations (until Thursday 24 Jan). But visitors are encouraged to explore beyond the capital throughout the year on a self-guided road trip.

    Renoir 100th France

    August Renoir died 100 years ago in December. The Eau et Lumière Association, which has created 12 "Impressionisms Routes" linking sites that inspired 12 European impressionist painters, has declared 2019 to be Renoir Year. It hopes to attract more art lovers to attractions on the Renoir Route—visitors to Paris could try the Museum of Montmartre and Renoir Gardens, where he once lived, or the Musée de la Grenouillère in nearby Croissy-sur-Seine, where he painted river scenes.

    It is a live celebration of the lasting power of letter writing!

    Letters Live, which started in December 2013, was held at the Freemasons' Hall in London from March 10 to 15. The show invited various great performers who read remarkable letters that had been written around the world over the centuries.

    "Bringing letters alive through outstanding performances is one of the most powerful ways in which the joy and pain and humor and tragedy of being human can be shared," Jamie Byng, managing director of Canongate Books publishing firm, told the Nowness video channel.

    British actor Benedict Cumberbatch agreed. "Letters are windows into the love, beauty, pain and humor of their creators and receivers," he told The Guardian. "Letters Live makes us stop and imagine the lives behind the letters read and where they came from. It's a great honor to read this most ancient of communications live to an audience."

    This year, the movie Sherlock star treated the audience by playing the part of a 17-year Tom Hanks. He put on the young actor's voice when he read his letter to the Hollywood director George Roy Hill, a letter that urged Hill to "discover" him. The letter showed that two-time Oscar winner Hanks' teenage dream was not to "be a big-time Hollywood superstar" but to one day own a Porsche car and call his favorite US actor Robert Redford his nickname "Bob".

    Other famous faces at the event included Carey Mulligan, who played a fictional laundry worker, a female activist fighting for women's rights in the 2015 movie Suffragette. The British actress once again played the role of a suffragette (女权主义者), when she read a very enthusiastic letter demanding the vote for women. The suffragette sent a precious 1913 note to The Daily Telegraph newspaper.

    “Everyone seems to agree upon the necessity of putting a stop to Suffragist anger, but no one seems certain how to do so, " Mulligan read out. "There are two, and only two, ways in which this can be done. Both will be effectual. One, kill every woman in the UK. Two, give women the vote."