Exercise may help to safeguard the mind against depression through previously unknown effects on working muscles, according to a new study involving mice.

    Mental health experts have long been aware that even mild, repeated stress can contribute to the development of depression and other mood disorders in animals and people. Scientists have also known that exercise seems to cushion against depression. But precisely how exercise, a physical activity can lessen someone's risk for depression, a mood state, has been mysterious. So for the new study, researchers at the Karolinska Institute in Stockholm studied the brains and behavior of mice in a complicated and novel fashion.

    We can't ask mice if they are feeling cheerful or in low spirits. Instead, researchers have pictured certain behaviors that indicate depression in mice. If animals lose weight, stop seeking out a sugar solution when it's available — because, probably, they no longer experience normal pleasures — or give up trying to escape from the cold-water zone just freeze in place, they are categorized as depressed. And in the new experiment, after five weeks of frequent but low-level stress, such as being lightly shocked, mice displayed exactly those behaviors. They became depressed.

    The scientists could then have tested whether exercise blunts (延缓) the risk of developing depression after stress by having mice run first. But, frankly, from earlier research, they wanted to know how, so they bred pre-exercised mice. A wealth of earlier research by these scientists and others had shown that aerobic exercise, in both mice and people, increases the production within muscles of an enzyme (酶) called PGC-1alpha. The Karolinska scientists suspected that this enzyme somehow creates conditions within the body that protect the brain against depression. Then, the scientists exposed the animals, which without exercising, were in high levels of PGC-1alpha to five weeks of mild stress. The mice responded with slight symptoms of worry. But they did not develop depression. They continued to seek out sugar and fought to get out of the cold-water zone. Their high levels of PGC-1alpha appeared to make them depression-resistant. Finally, to ensure that these findings are relevant to people, the researchers had a group of adult volunteers complete three weeks of frequent endurance training, consisting of 40 to 50 minutes of moderate cycling or jogging. The scientists conducted muscle biopsies (活体检查) before and after the program and found that by the end of the three weeks, the volunteers' muscle cells contained substantially more PGC-1alpha than at the study's start. The finding of these results, in the simplest terms, is that “you reduce the risk of getting depression when you exercise,” said Maria Lindskog, a researcher at the Karolinska Institute.

    English is full of colorful phrases to describe shyness. Someone shy might be called shrinking violet or a wallflower, while for especially nervous types we have the curious expression: they wouldn't say boo to a goose.

    None of these are traditionally seen as positive descriptions, even if you like geese. In a culture of go-getting, high achievers, shy people don't come first. Or that's what the self-help industry would have you believe. Bookshops are filled with vital tomes(巨著) that promise to help beat social fears and find success in life, love and business. That is why one book, Shrinking Violets: A Field Guide to Shyness, bucks the trend. It became a sudden success across English-language media recently for its new take-on shyness.

    Author Joe Moran says that despite struggling with shyness and longing for loneliness all his life, being shy can also be "a gift". Freed from the constant urge to participate and compete in social situations, people are liberated to look at the world in new ways, and gain fresh insights.

    Indeed, many of the world's great thinkers and artists are introverts(内向的人). Scientists Charles Darwin and Albert Einstein preferred their own company; actress Keira Knightley often finds herself tongue-tied at parties; and Harry Potter author JK Rowling claims she used to be too nervous to even borrow a pen.

    Moran told BBC Future: "I think shyness probably does turn you into an amateur anthropologist(人类学家), really-you are more likely to be an observer."

    So, while extroverts make all the noise, they don't necessarily have the best ideas.

    If you're shy, you've probably known this for a long time. You just don't shout about it.

People aren't walking any more—if they can figure out a way to avoid it.

    I felt superior about this matter until  the other day I took my car to mail a small parcel. The journey is a matter of 281 steps. But I used the car. And I wasn't in ay hurry, either, I had merely become one more victim of a national sickness: motorosis.

    It is an illness to which I had thought myself immune（免疫的）, for I was bred in the tradition of going to places on my own two legs. At that time, we regarded 25 miles as good day's walk and the ability to cover such a distance in ten hours as sign of strength and skill. It did not occur to us that walking was a hardship. And the effect was lasting. When I was 45 years old I raced –and beat—a teenage football player the 168 steps up the Stature of Liberty.

Such enterprises today are regarded by many middle-aged persons as bad for the heart. But a well-known British physician, Sir Adolphe Abrhams, pointed out recently that hearts and bodies need proper…… is more likely to have illnesses than one who exercises regularly. And wlaking is an ideal form of exercise— the most familiar and natural of all.

    It was Henry Thoreau who showed mankind the richness of going on foot. The man walking can learn the  trees, flower, insects, birds and animals, the significance of seasons, the very feel of himself as a living creature in a living world, He cannot learn in a car.

    The car is a convenient means of transport, but we have made it our way of life. Many people don't dare to approach Nature any more; to them the world they were born to enjoy is all threat. To them security is a steel river thundering on a concrete road. And much of their thinking takes place while waiting for the traffic light to turn green.

    I say that the green of forests is the mind's best light. And none but the man on foot can evaluate what is basic and everlasting.

    One day when I was 12, my mother gave me an order: I was to walk to the public library, and borrow at least one book for the summer. This was one more weapon for her to defeat my strange problem—inability to read.

    In the library, I found my way into the "Children's Room." I sat down on the floor and pulled a few books off the shelf at random. The cover of a book caught my eye. It presented a picture of a beagle. I had recently had a beagle, the first and only animal companion I ever had as a child. He was my secret sharer, but one morning, he was gone, given away to someone who had the space and the money to care for him. I never forgot my beagle.

    There on the book's cover was a beagle which looked identical (相同的)to my dog. Iran my fingers over the picture of the dog on the cover. My eyes ran across the title, Amos, the Beagle with a Plan. Unknowingly, I had read the title. Without opening the book, I borrowed it from the library for the summer.

    Under the shade of a bush, I started to read about Amos. I read very, very slowly with difficulty. Though pages were turned slowly, I got the main idea of the story about a dog who, like mine, had been separated from his family and who finally found his way back home. That dog was my dog, and I was the little boy in the book. At the end of the story, my mind continued the final scene of reunion, on and on, until my own lost dog and I were, in my mind, running together.

    My mother's call returned me to the real world. I suddenly realized something: I had read a book, and I had loved reading that book. Everyone knew I could not read. But I had read it. Books could be incredibly wonderful and I was going to read them.

    I never told my mother about my "miraculous" (奇迹般的) experience that summer, but she saw a slow but remarkable improvement in my classroom performance during the next year. And years later, she was proud that her son had read thousands of books, was awarded a PhD in literature, and authored his own books, articles, poetry and fiction. The power of the words has held.

    If you have a chance to go to Finland, you will probably be surprised to find how "foolish" the Finnish people are.

    Take the taxi drivers for example. Taxis in Finland are mostly high-class Benz with a fare of two US dollars a kilometer. You can go anywhere in one, tell the driver to drop you at any place, say that you have some business to attend to, and then walk off without paying your fare. The driver would not show the least sign of anxiety.

    The dining rooms in all big hotels not only serve their guests, but also serve outside diners. Hotel guests have their meals free, so they naturally go to the free dining rooms to have their meals. The most they would do to show their good faith is to wave their registration card to the waiter. With such a loose check, you can easily use any old registration card to take a couple of friends to dine free of charge.

The Finnish workers are paid by the hour. They are very much on their own as soon as they have agreed with the boss on the rate. From then on they just say how many hours they have worked and they will be paid accordingly.

    With so many loopholes in everyday life, surely Finland must be a heaven to those who love to take "petty advantages". But the strange thing is, all the taxi passengers would always come back to pay their fare after they have attended to their business; not a single outsider has ever been found in the free hotel dining rooms. And workers always give an honest account of the exact hours they put in. As the Finns always act on good faith in everything they do, living in such a society has turned everyone into a real "gentleman".

    You are given many opportunities in life to choose to be a victim or creator. When you choose to be a victim, the world is a cold and difficult place. "They" did things to you which caused all of your pain and suffering. "They" are wrong and bad, and life is terrible as long as "they" are around. Or you may blame yourself for all your problems, thus internalizing (内化) your victimization. The truth is, your life is likely to stay that way as long as you feel a need to blame yourself or others.

    Those who choose to be creators look at life quite differently. They know there are individuals who might like to control their lives, but they don't let this get in the way. They know they have their weaknesses, yet they don't blame themselves when they fail. Whatever happens, they have choice in the matter. They believe their dance with each sacred (神圣的) moment of life is a gift and that storms are a natural part of life which can bring the rain needed for emotional and spiritual growth.

    Victims and creators live in the same physical world and deal with many of the same physical realities, yet their experience of life is worlds apart. Victims relish (沉溺) in anger, guilt, and other emotions that cause others — and even themselves — to feel like victims, too. Creators consciously choose love, inspiration, and other qualities which inspire not only themselves, but all around them. Both victims and creators always have choice to determine the direction of their lives.

    In reality, all of us play the victim or the creator at various points in our lives. One person, on losing a job or a special relationship, may feel as if it is the end of the world and sink into terrible suffering for months, years, or even a lifetime. Another with the same experience may choose to first experience the grief, then accept the loss and soon move on to be a powerful creative force in his life.

    In every moment and every circumstance, you can choose to have a fuller, richer life by setting a clear intention to transform the victim within, and by inviting into your life the powerful creator that you are.