Allow me to introduce you to Terry, a window salesman from England. If I could take you back about 20 years, you'd know Terry as a complete green hand, who was wet behind the ears in just about everything he attempted. A person couldn't sell false teeth to his own Granny, let alone he could compete with the other salespeople in the industry. You know, the kind who could sell snow to Eskimos.

    Terry's boss decided to send him out on a practical field trip on his first day. So off he went, but he was extremely nervous. With his hands and his knees shaking, he approached the front door and knocked at it. And an old woman appeared. After dozens of cups of tea and pieces of biscuits, the woman signed a contract and purchased over $7,000 worth of windows.

    The woman had already talked with 6 excellent salesmen that week, all of whom offered her cheaper ones! That's right—Terry's price was the most expensive and he was also the most inexperienced salesman there ever was.

    So, what happened then? Here comes the secret. The woman said she liked the young lad more than the others. That's all there was to it. She didn't care about the extra expense. Even the other salesmen couldn't persuade her to pay less than this young lad was asking for.

    The truth is that the young lad left on the woman the first impression that shone brighter than any of the salesman's talk. First impressions count, not the sales techniques, not the low prices. The actual “personality” the kid honestly gave was all that was required. If you market your own products and services, consider what impression you are giving to others. If you appeal to them, then you've already done half of the work. If this means redesigning your presentation, then so be it. If this means going out of your way to be polite, helpful and giving the best possible shopping experience to your customers, the so be it.

    Welcome to one of the largest collections of footwear（鞋类）in the world that will make you green with envy. Here at the Footwear Museum you can see exhibits（展品）from all over the world. You can find out about shoes worn by everyone from the Ancient Egyptians to pop stars.

    What will people die of 100 years from now? If you think that is a simple question, you have not been paying attention to the revolution that is taking place in bio-technology(生物技术). With the help of new medicine, the human body will last a very long time. Death will come mainly from accidents, murder and war. Today's leading killers, such as heart disease, cancer, and aging itself, will become distant memories.

    In discussion of technological(技术的) changes, the Internet gets most of the attention these days. But the change in medicine can be the real technological event of our times. How long can humans live? Human brains were known to decide the final death. Cells are the basic units of all living things, and until recently, scientists were sure that the life of cells could not go much beyond 120 years because the basic materials of cells, such as those of brain cells, would not last forever. But the upper limits will be broken by new medicine. Sometime between 2050 and 2100, medicine will have advanced to the point at which every 10 years or so, people will be able to take medicine to repair their organs（器官）. The medicine, made up of the basic building materials of life, will build new brain cells, heart cells, and so on—in much the same way our bodies make new skin cells to take the place of old ones.

    It is exciting to imagine that the advance in technology may be changing the most basic condition of human existence, but many technical problems still must be cleared up on the way to this wonderful future.

    Metropolis Book Club

    Membership:

    All you need to do is fill out the order form at the bottom of the page, select your first order from our book list and then post the completed form back to us.

    Special offers for new members:

    As a special offer, you may choose any reduced-price books from our new members' book list, to the value of 100 yuan in total.

    Tick the box on your form to order a free watch.

    Join before the end of this month and you receive another free book carefully chosen by our staff.

    Order an audio-book from the many on offer, at half the recommended retail price.

    When you've joined:

    As a member you get around 50% off the publisher's price of every book you buy, and what's more, they come straight to your door. Your free club magazine arrives once a month to keep you up to date with the latest best-sellers we've added to our list. On the Internet, you can find all our titles for the year at our exclusive members' website. Our website also has a book swap service where members can request or offer books for exchange.

    Being a member:

    All you have to do is order four books during your first year. After that, you can decide on the number of books you wish to take.

    In each of your monthly club magazines, our experienced staff choose a "Book of the Month" for you, which is offered at an extra-special price. If you do not want this book, just say so in the space provided on the form and send it back to us. We always send the book if we do not receive this form.

    Once we receive your order, your books are delivered within one week. And remember, you have up to a fortnight to decide if you wish to keep the books you have ordered. If they aren't what you expected just send them back!

    Depression(抑郁) can be a destructive illness, plaguing millions of people worldwide with feelings of sadness, hopelessness, and fatigue. Despite numerous antidepressant drugs, as many as a third of patients don't respond to medication. This has forced doctors to be more creative in finding different treatments for the condition.

    In the past two decades, researchers have tied depression to a seemingly unrelated condition: inflammation(炎症), the body's natural response to stress. It could rise from injury or inflection, or even emotional issues like an unhappy marriage or problems at work. Some amount of inflammation is generally beneficial, as it increases production of cytokines(致癌因子)，proteins that help us heal and protect us from the effects of overwork.

    But excessive cytokine levels, and the inflammation they bring on, could come at a cost—a number of studies suggests that high levels of cytokines could contribute to depression.

    Cytokines can reach the brain several ways: directly through the blood-brain barrier or indirectly by binding to nerve fibers elsewhere, which send signals to the brain to produce the inflammation molecules. In the brain, cytokines can disturb the production and release of several important signaling chemicals, including serotonin, dopamine and glutamate, which help control emotion, appetite, sleep, learning and memory. It's though that a lack of serotonin activity in the brain causes depression; most antidepressants increase the activity. But cytokines also have been shown to activate stress hormone signaling in the brain, which man also serve to develop depression.

    With all the evidence implicating inflammation in depression, doctors have been anxious to test anti-inflammatory drugs as a potential treatment. Four small studies published between 2006 and 2017 by research groups in Europe and Iran found that adults diagnosed with depression who took aspirin or another anti-inflammatory drug called Celecoxib, along with an antidepressant, got more relief from feelings of sadness, hopelessness, guilt and fatigue compared with those taking an antidepressant alone. However, Andrew Miller, a professor of psychiatry at Emory University, thought something was wrong in these small, limited studies. None of them looked at whether the participants had to have high levels of cytokines before they'd see a benefit from anti-inflammatory drugs.  "Unfortunately, much of the field has fallen into the trap of viewing inflammation as the be-all, end-all," Miller says. He and his colleagues wanted to see whether the effect of these drugs was limited to the depression patients with high cytokine levels, or if it helped all people diagnosed with depression.

Instagram(图片分享社交应用程序)is about to take its biggest step toward removing likes from its platform. After months of testing an option to hide likes in select international markets, Instagram, which is owned by Facebook(FB), has already been testing hiding likes in seven other countries, including Canada, Ireland and Australia. For years, likes have been central to how celebrities, brands, politicians and everyday users experience Instagram and Facebook. It's a way of measuring popularity(名气) and success. But in recent months, Instagram has been rethinking how likes contribute to making its platform more toxic. Now it's considering a change.

The total number of likes on posts — which appear as hearts on the app—will disappear from Instagram's main feed, profile pages and permalink(永久链接)pages. The owner of the account can still see their own likes, but their followers won't know the count.

CNN Business previously spoke with users in countries with the test. The majority felt this move would improve well-being on the app. Instagram is the most harmful social networking app for young people's mental health, such as negatively influencing body image, according to one study.

But other users and psychologists said hiding likes won't fix everything. The test doesn't address some of the key ways that activity on Instagram can influence the well-being of users, including bullying(欺凌), feeling left out and thinking other people's lives are better than their own.

Renee Engeln, a psychology professor at Northwestern University, voiced his opinion that the biggest impact of Instagram is the content and the exposure to this constant stream of perfected images is what seems to hurt psychologically. Plus, users can still see their own likes—and feel badly if their posts don't perform well.