Here's an idea whose time has come: A flu shot that doesn't require an actual shot.

    For the first time, researchers have tested a flu vaccine patch (疫苗贴) in a human clinical trial and found that it delivered as much protection as a traditional injection with a needle. Doctors and public health experts have high hopes that it will increase the number of people who get immunized (免疫的) against the flu.

    Seasonal flu is responsible for up to half a million deaths around the world each year according to the World Health Organization. A team led by Georgia Tech engineer Mark Prausnitz has come up with an alternative method that uses “microneedles”. These tiny needles are so small that 100 of them, arranged in order on a patch, can fit under your thumb (拇指).Yet they're big enough to hold vaccine for three types of flu.

    None of the study volunteers had serious side effects. The groups that got patches had mild skin reactions that were not seen in the regular needle group, while the volunteers in the regular needle group were more likely to experience pain. Overall, 70 percent of the volunteers who got vaccine patches said they'd rather use them again than get a traditional flu shot. The study authors declared it a success on all fronts.

    The biggest beneficiaries could be people in low- and middle-income countries, where flu vaccines are hard to come by. Reducing pain is nice, but other benefits—the patch costs less，is easier to transport, doesn't require refrigeration, can be self - administered and doesn't cause waste of needles—are even better.

    “Microneedle Patches have the potential to become ideal candidates for vaccination programs,” wrote Katja Hoschler and Maria Zambon of Public Health England.

    One form of social prejudice against older people is the belief that they cannot understand or use modern technology. Activities like playing computer games, going on the Net and downloading MP3s are only for the youngsters. Isn't it unfair that older people enjoying a computer game should be frowned（皱眉）upon by their children and grandchildren?

    Nowadays older people have more control over their lives and they play a full part in society. Moreover, better health care has left more people in their sixties and seventies feeling fit and active after retirement. Mental activity, as well as physical exercise, can contribute to better health. Playing computer games is a very effective way of exercising the brain.

    When personal computers were first introduced, most older people didn't believe they would ever familiarize themselves with it. Now computers have been around for a few generations and retired people have gradually become more relaxed about using them for fun. Gamers over 65 prefer playing puzzle games and card games. Kate Stevens, aged 72, says: “I find it very relaxing. It's not very demanding, but you still need to concentrate.”

    Another development that has favored “grey games” is a change in the type of videogames available on the market. There's a greater variety of games to choose from, including more intellectual and complex strategy（策略）and simulation（模拟）games. Internet Chess and Train Simulator are among the most popular of these. Train Simulator is based on real-world rail activities. Players can choose from a variety of challengers, such as keeping to a strict-timetable and using helper engines during a winter storm.

    Some people argue that “grey gamers” simply don't have the skills required for computer games, and that teenagers are better.  This couldn't be further from the truth. Most computer games require the kind of analytical thinking that improves with practice, which means that the “grey gamers: may well be far better than gamers half a century younger than them. In games where speed is the main consideration, older people would be at a disadvantage because they may have slower reaction time. On the other hand, “grey gamers” have a preference for shower paced, mind challenging games.

    "Mom, what is that?" asked my son. "The Bride of Chucky?"

    The old doll I was holding was pretty scary. Her glass eyes were especially horrible, closing when she stood upright and flying open when she lay flat. Once she had been loved, but she had been stored in an attic (阁楼) for decades, where the extremes of heat and cold can be hard on a girl's looks. Throw her in the waste bin? Maybe. But first, let's check eBay.

    I clicked, supplied the required information about condition, including defects (i.e., "Only a miracle could save this doll"), and uploaded its photos. I sold it for $5.

    The buyer was happy: "As described!" he wrote on my feedback page. "Super seller!" The doll found a home and, I hope, a new life. Maybe she was used to repair other dolls. Perhaps those strange eyes got fixed and once again can inspire a child's love. It's a win-win, if you ask me.

    I also sold lots of other stuff. None of them brought in a lot of money, though I have been surprised at the occasional bidding war, like, for example, the one over an old swimsuit that would have made Brigitte Bardot look bad. And some customers, let's face it, are strange. Recently I had a hard time convincing an Australian would-be buyer of an Irish souvenir bell that I don't shop internationally; it's just too much trouble. He could have flown to Ireland and bought his own bell for the price he was willing to pay. Another time, a buyer complained that the electric wire on an old radio was dirty. Really? Dirty? The wire was black. But I aim to please, so I offered a refund.

    So why bother with the dealing and small profits? Because I don't like abandoning the past. All these treasures once had stories. They meant something. But the people who gave them that meaning are gone, and I simply cannot rescue everything. I can't even sew. So I find it satisfying that a new owner, discovered via eBay, will continue the story in his or her own way.

Rich as a King

    William 1, who conquered England some 930 years ago, had wealth, power and an army. Yet although William was very rich by the standard of his time, he had nothing like a flush toilet (抽水马桶), paper towels, or riding lawn mower (除草机). How did he get by?

    History books are filled with wealthy people who were poor compared to me. I have storm windows, Croesus did not. Entire nations trembled before Alexander the Great, but he couldn't buy cat food. Czar Nicholas lacked an electric saw.

    Given how much better off I am than so many famous dead people, you'd think I'd be content. The trouble is that, like most people, I compare my wealth with that of living person: neighbors, school classmates, famous TV people. The greed I feel toward my friend Howard's new kitchen is not reduced by the fact that no kings ever had a refrigerator with glass doors,

    There is really no rising or falling standard of living. Over the centuries people simply find different things to feel sad about. You'd think that simply not having disease would put us in a good mood, but no we want a hot bath too.

    Of course, one way to achieve happiness would be to realize that even by today's standards the things I own are pretty nice. My house is smaller than the houses of many investment bankers, but even so it has a lot more rooms than my wife and I can keep clean.

    Besides, to people looking back at our era from a century or two in the future, these bankers' fancy counter tops and my awn worn Formica will seem equally shabby, I can't keep up with my neighbors right now. But just wait.

    The world is too big to take in all at once. To make sense and beauty of it, you have to look at a small part at a time.

    In using a camera, you choose a small part through he view finder. You move the camera, "framing" pictures until you see one that pleases you. Then-click! If you make a good choice, your picture will please others, as well as yourself.

    "Wherever you are," says photographer Ernst Haas, "you are surrounded by pictures. The trick is to recognize them." His photograph of a twist of barbed wire shows what he means.

    Mr. Haas tells us of ways to practice seeing. Make a simple frame of black cardboard. Take it out of the doors and look through it at everyday things, large or small, far away or near.

    At first you may see nothing to interest you. But soon pictures seem to leap (跳) at you through the frame. Oil floating on water makes a picture in rainbow colors. Three people on the steps of an old house form a picture that seems to tell a story.

    Did you notice such things before you used the frame? Perhaps not. But, with practice, you soon do not need its help. You see things as artists do. Everywhere, shapes and colors catch your eye. Your mind takes "snapshots (快照)" of their patterns. Then, if you wish, you can share what you see by taking a photograph or by making a drawing or a painting.

    Sometimes it's fun to "see small". Did you ever notice the design of the seeds in sliced bananas? Have you looked deep inside a lily? Or seen the starburst in the center of a wet ice cube?

    Do you see colors as they really are? When you paint tree trunks, you would make them brown or black. But tree trunks are really gray, purple, yellow-green—almost any color except brown or black!

    Do you notice detail? Doing so can be in many ways. Remembering what you see is often useful, too. Practice can help you.

    A trick for helping you to remember detail is the double take. Look—don't look—then look again.

Jean was a teacher who taught first grade. She drove an old Jetta with dull blue paint and worn seats. It wasn't the speediest tool, but Jean was never late to work. In fact, each school day she was the first teacher to arrive and the last teacher to leave.

She took great care to plan instruction, create assessments, and decorate her classroom. Parents in the neighborhood would beat down the principal's door to have their children arranged to her class. Jean could teach a mouse to read, and all her students passed into second grade with advanced vocabularies and language skills.

One August, two sisters in high school did not want to enter foster care (家庭寄养). They contacted their first grade teacher, Jean. Jean lived in quite an ordinary home with her son. Yet, she took the sisters in. Packed with children, the little blue Jetta sputtered (劈啪作响), but they had a good laugh.

One day, Jean spoke about her car, which she had driven for many years and had been old enough to retire. It was kind of dangerous for students to ride in such a car. She wanted a van. However, a new van was not within her ability. As a good friend, I listened to her concerns. Then, an idea came to me. I wrote a letter to The Oprah Winfrey Show, sharing Jean's story and her wish.

A month passed. Jean was invited to attend The Oprah Winfrey Show. Oprah hugged the teacher and told the details of Jean's story. Oprah announced that Jean deserved a new van.

The year was 1999. Six hundred miles away, I watched the joy of it all from the television. Jean's big heart taught me many lessons that year. One of them is that the simplest acts (like writing a letter) can require a strong faith. And nothing impossible.