Your New Year's plan to move more is one of the toughest to stick to, and a group of scientists working with obese(过度肥胖的) mice think they're starting to understand why

    Rather than our sedentary(久坐的) lives causing weight gain, says Alexxai Kraviz, the National Institutes of Health neuroscientist who led the study, changes in brain chemistry after we start gaining weight affect our capacity to move.

    “Obses mice can move just fine,” says Kravitz, who published the work with his team in Cell Metabolism “They just don't.”

    What Kravitz's team found is that the activity of a particular dopamine(多巴胺) receptor linked to movement goes down as mice gain weight on a high-fat diet. So the nice slow down and they move less. And when the researchers restored the activity of that dopamine receptor—DR2—the mice started moving more, even though they were still obese. The team also saw that lean mice missing the DR2 receptor acted like obese mice. This is the target, says Kravitz—restoring that dopamine receptor function. “Maybe 20 or 30 years down the road, we could do that in people,” he says.

    And there is one more thing: The scientists fed normal mice and the mice lacking DR2 the same high-fat diet. Both sets of mice gained weight at the same rate.

    Kravitz says this is important because mice lacking DR2 move less from the get-go, whereas a normal mouse takes a little time to start seeing that dopamine receptor-related loss of exercise. The ability to exercise seems to be disconnected from weight gain, he says.

    “Exercise is a healthy thing to do, but its impact on weight loss has been exaggerated,” he says. “We have to be realistic about the size of the effect of exercise on weight, as opposed to health benefits.”

    Still, before you abandon your New Year's exercise plan, keep in mind that this study was done using a high-fat diet, and not the normal calorie restriction that people maintain when they diet.

    That's a big drawback to the work, says Vicki Vieira-Potter, a University of Missouri physiologist not involved in the study.

    “They feed the mice with high-fat diet, it damages the receptor, and that decreases activity. Those who plan to lost weight should remember high-fat diet is a nice way to cause obesity in the lab, but it's not the same as the normal situation of obesity,” she says.

    Sine also says that a lot of the weight gain in the mice came after they stopped moving around, which indicates that the loss of movement did impact obesity.

Events listed here are open to everyone. Whether you want to listen to a lecture, learn a new skill, take in a concert or an exhibition, see a play staged by Oxford University students or attend one of our sporting events, there's always something going on.

    Events are subject to change; please contact the organizer for full details.

    Qu Leilei: A Chinese Artist in Britain

    30 November 2017 to 15 April 2018

Contemporary Chinese artist Qu Leilei (born in 1951), now based in London, was a founding member of the creative ‘Stars Group' in the late 1970s, and immigrated to England in 1985. This exhibition shows his progression from calligraphic (书法的) art to an exploration of a new vocabulary of ink language mixing lively brushwork with western technique.

    The Brexit (脱欧) sword hanging over our universities

    29 November 2017

    Lord Bilimoria CBE，the Founder and Chairman of Cobra Beer and President of the University of Birmingham, will talk about Brexit, its influence on our universities, their academics and students as well as the future of international students in the UK.

    Oxford Botanic Garden Christmas Fair

    2-3 December 2017

    Escape the crowds and step inside a wonderland of hand-picked gifts, tasty food and family entertainment. Look through for extra-special Christmas presents at over 30 stands in the heated large tent. Pause for a glass of sweet hot wine and some delicious food, then follow the Alice in Wonderland path around the walled garden before stopping for tea with the Mad Hatter.

    The Art of Partying: A Feast for the Eyes!

    13 December 2017

    From Greek designs and Biblical weddings to Renaissance works and the celebratory styles of the twentieth-century painters, this lecture will examine the popular description of parties in the history of Western Art at the Ashmolean Museum.

    In England, we look forward to our birthdays for 364 days a year! We invite special people to celebrate it with us.

    The Presents

    Presents are opened as soon as the children are awake. They can't wait for the birthday cake later in the day!

    The Cards

    Friends and family send birthday cards. Sending birthday cards is a custom that began in England about 100 years ago.

    The Party

    The birthday child will have a party to which friends and family are invited. Visitors to the party bring presents for the birthday child. The children play games such as Musical Chairs and Pass the Parcel.

    The Cake

    The birthday cake is decorated on a theme(主题). A candle for each year is lit and placed on top and the child blows out the candles making a wish. We don't put objects inside the cake as shown on many websites.

    The Bumps

    It used to be traditional for the birthday child to have the bumps. Friends would hold the child by the child by the legs and under the arms and lift the child up and down bumping them gently on the ground. The number of bumps given is the age of the child plus one for extra good luck. As this can be dangerous, clapping is often done instead.

    The Sweets

    Some children do take sweets into school to share with their classmates on their birthdays.

    Jimmy is an automotive mechanic (汽车修理技工), but he lost his job a few months ago. He has a good heart, but always feared applying for a new job.

    One day, he gathered up all his strength and decided to attend a job interview. His appointment was at 10 a.m. and it was already 8:30. While waiting for a bus to the office where he was supposed to be interviewed, he saw an elderly man wildly kicking the tyre of his car. Obviously there was something wrong with the car. Jimmy immediately went up to lend him a hand. When Jimmy finished working on the car, the old man asked him how much he should pay for the service. Jimmy said there was no need to pay him; he just helped someone in need, and he had to rush for an interview. Then the old man said, "Well, I could take you to the office for your interview. It's the least I could do. Please, I insist." Jimmy agreed.

    Upon arrival, Jimmy found a long line of applicants waiting to be interviewed. Jimmy still had some grease (油渍) on him after the car repair, but he did not have much time to wash it off or have a change of shirt. One by one, the applicants left the interviewer's office with disappointed looks on their faces. Finally his name was called.  The interviewer was sitting on a large chair facing the office window. Rocking the chair back and forth, he asked, "Do you really need to be interviewed?" Jimmy's heart sank. "With the way I look now, how could I possibly pass this interview?" He thought to himself.

    Then the interviewer turned the chair and to Jimmy's surprise, it was the old man he helped earlier in the morning. It turned out that he was the General Manager of the company.

    "Sorry I had to keep you waiting, but I was pretty sure I made the right decision to have you as part of our workforce (职工) before you even stepped into this office. I just know you'd be a trustworthy worker. Congratulations!" Jimmy sat down and they shared a cup of well-deserved coffee as he landed himself a new job.

Membership Card

    Fighting Fit is a members-only club. When you first join, we give you a computerized card. It has your name, photo and membership number on.

    Please have your card with you every time you use the club. The card is for your use only, and there is a small charge to provide a new one if you lose it. Members are permitted to bring guests to use the facilities at the club. A visiting guest fee is charged for each guest.

    Fitness Programs

    Your Fitness Program includes a meeting with one of our skilled instructors. This will happen two or three weeks after you have joined. The instructor looks at your health, your current needs and the way you live, and organizes a program suitable for you.

    Gymnasium

    Our gymnasiums are the most modern in the area and have high quality exercise equipment. For safety reasons, you must wear sportswear and trainers while exercising, and please remember to take a small towel too. It is one of our rules that you wipe the equipment after use.

    There is no limit to how long you spend in the gymnasiums, but we ask you to respect other members by only spending 20 minutes on each piece of equipment. There are experienced staff helping you in the gymnasiums at any time.

    Locker Rooms

    We have large male and female locker rooms. Please ensure that your property is kept in your locker at all times. Any belongings which are found in a locker overnight will be removed and taken to Lost Property.

    Café

    The Café offers free tea, coffee and soft drinks.

    Suggestion Box

    Members' suggestions are always welcome, and the suggestion box and forms can be found at reception. We try to respond within two days.

Ivan Pavlov was a Russian physiologist (生理学家) best known for his discovery of classical conditioning (经典条件反射). During his studies on the digestive systems of dogs, Pavlov found that the animals salivated (流口水) naturally upon the presentation of food. However, he also noticed that the animals began to salivate whenever they saw the white lab coat of an experimental assistant. By associating the presentation of food with the lab assistant, he finally found that a dog would salivate to the presence of a stimulus (刺激物) other than food. He called this response a conditional reflex.

Ivan Pavlov was born in a small village in Ryazan. Russia, where his father was the village minister. His earliest studies were focused on theology (神学), but reading Charles Darwin's On the Origin of Species had a powerful influence on his future interests. He soon stopped his religious studies and devoted himself to the study of science at the University of Saint Petersburg. Pavlov's interests were the study of physiology and natural sciences. He helped found the Department of Physiology at the Institute of Experimental Medicine and continued to manage the program for the next 45 years.

Pavlov received much praise for his work. He worked in the Russian Academy of Science and won the 1904 Nobel Prize in Physiology. The Soviet government also offered lots of support for Pavlov's work, and the Soviet Union soon became a leading center of research on physiology. While Ivan Pavlov was not a psychologist, and reportedly disliked the field of psychology, his work had a major influence on the field, particularly on the development of behaviorism. His discovery and research on reflexes influenced the growing behaviorist movement. and Pavlov's discovery had a major influence on many thinkers, such as John B. Watson.