Avatar has become the most successful movie in 2009. It is about a soldier whose mind is set into the body of a giant blue alien. He was sent to a dangerous planet called Pandora. His mission（使命） is to find a rare mineral（矿物质）. The mineral is the key to solve the earth's energy crisis(危机).

    According to the latest figures（数字）, Avatar has become the fastest film ever to make more than 1 billion dollars in ticket sales around the world. When it had been shown in cinemas for several days, it became the most popular film ever made.

    Avatar knocked the movie Titanic off the international release top spot. But Titanic's director James Cameron probably won't be too upset, because Avatar is directed by him as well! Before Avatar was filmed, the best selling film ever was Titanic.

    James Cameron decided to make Avatar in 1999. However, the means（方法）to realize his vision（影像画面） did not exist yet. In 2002, The Lord of the' Rings: The Two Towers made him believe that CGI (电脑影像合成) effects had progressed enough to make this film. After several years of production, the 3D spectacular Avatar successfully showed us a fully immersive experience.

    Have you ever noticed that the more you have the more you want? Let's face it. Thinking our life is good enough doesn't come naturally to many people. When we have high expectations of everything in life we will run into disappointment. Only when we are aware that needs are different from desires can we live with satisfaction. Here are a few ideas to help you be happier with what you have and who you are.

    Focus on what you are thankful for. Most people want things to be better than they are, or when things are going well, we forget to appreciate what we have. Learn to reflect on how much better things are than they could be. Focus on what you are thankful for. Write down 5 things you are grateful for right now.

    When we hold onto regrets from decisions we have made, it can really poison our well-being. Many people regret something they can no longer change, which ends up holding them back from moving forward in a more positive manner. What happened in the past is done and gone, so work to stay present and be mindful of the current moment to find more joy and fulfillment.

    When we use other people as the measuring stick for our personal success and quality of life we are likely to be less satisfied. Social comparisons can provide useful information when we try to learn from others, but they also hold our perspective in a discontented position. Compare yourself less with others so you can be satisfied more.

    When you are focused on your big ambitions and future goals you might elide the daily pleasures that surround you. Learn to slow down and absorb the wonder and beauty around you. Stay present and focus on the task you're undertaking at the moment. Don't let the life pass you by because you're always on the go and distracted by ambition.

    Practice looking at life through the lens of contentment and it will become more natural.

    Teachers' Day is, interestingly, not celebrated on the same day all over the world. In some countries it is marked by a holiday, in others it is a working day.

    International Teachers' Day is celebrated on October 5. Being held ever since 1994, it is in honor of teachers' organizations worldwide. Its aim is to encourage supports for teachers and to meet the needs of students.

    China   In 1939, Teachers' Day was set for August 27, Confucius' birthday. In1951, the celebration was stopped. However, it was founded again in 1985, and the day was changed to September 10.

    India   Teachers' Day is celebrated on September 5 in honour of Dr. Sarvepalli Radhakrishnan, the second president of India, whose birthday falls on that day.

    Russia   In Russia, Teachers' Day was celebrated on the first Sunday of October between 1965 and 1994. Since 1994, the day is observed on the October 5, just the same day as World Teachers Day.

    The US   In the US, Teachers' Day is non-official holiday. It is celebrated on the Tuesday of the first full week of May. A number of activities are organized in schools to honor teachers. The celebrations can continue for the whole week of May.

    Thailand   In Thailand, National Teachers' Day is celebrated every year on January 16. The first Teachers' Day was held in 1957. The day is a holiday in schools.

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

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