Your New Year's plan to move more is one of the toughest to stick to, and a group of scientists working with obese(过度肥胖的) mice think they're starting to understand why

    Rather than our sedentary(久坐的) lives causing weight gain, says Alexxai Kraviz, the National Institutes of Health neuroscientist who led the study, changes in brain chemistry after we start gaining weight affect our capacity to move.

    “Obses mice can move just fine,” says Kravitz, who published the work with his team in Cell Metabolism “They just don't.”

    What Kravitz's team found is that the activity of a particular dopamine(多巴胺) receptor linked to movement goes down as mice gain weight on a high-fat diet. So the nice slow down and they move less. And when the researchers restored the activity of that dopamine receptor—DR2—the mice started moving more, even though they were still obese. The team also saw that lean mice missing the DR2 receptor acted like obese mice. This is the target, says Kravitz—restoring that dopamine receptor function. “Maybe 20 or 30 years down the road, we could do that in people,” he says.

    And there is one more thing: The scientists fed normal mice and the mice lacking DR2 the same high-fat diet. Both sets of mice gained weight at the same rate.

    Kravitz says this is important because mice lacking DR2 move less from the get-go, whereas a normal mouse takes a little time to start seeing that dopamine receptor-related loss of exercise. The ability to exercise seems to be disconnected from weight gain, he says.

    “Exercise is a healthy thing to do, but its impact on weight loss has been exaggerated,” he says. “We have to be realistic about the size of the effect of exercise on weight, as opposed to health benefits.”

    Still, before you abandon your New Year's exercise plan, keep in mind that this study was done using a high-fat diet, and not the normal calorie restriction that people maintain when they diet.

    That's a big drawback to the work, says Vicki Vieira-Potter, a University of Missouri physiologist not involved in the study.

    “They feed the mice with high-fat diet, it damages the receptor, and that decreases activity. Those who plan to lost weight should remember high-fat diet is a nice way to cause obesity in the lab, but it's not the same as the normal situation of obesity,” she says.

    Sine also says that a lot of the weight gain in the mice came after they stopped moving around, which indicates that the loss of movement did impact obesity.

    Sometimes when I'm flying from one speaking engagement to another, I find myself sitting next to someone who's quite talkative. This is often a pleasant experience for me because I'm a people-watcher. I learn so much by watching and listening to the people I meet and see every day. I've heard stories of sadness and others of delight, fear and joy, and others that would rival those on “Oprah” and "Geraldo”.

    Sad to say，there are times when I'm sitting next to someone who just wants to vent(发泄） his temper or inflict(强加）his political views on an audience for 600 miles. It was one of those days. I settled in, as my seatmate began his speech on the terrible state of the world with the time worn, “You know, kids today are...” He went on and on, sharing vague notions of the terrible state of teens and young adults, based on watching the six o'clock news rather selectively.

    When I gratefully got off that plane and finally made it to my hotel in Indianapolis, I bought the local paper and went to have dinner in the hotel. There, on an inside page, was an article I believe ought to have been the front-page headline news.

In a little Indiana town, there was a 15-year-old boy with a brain tumor. He was undergoing radiation and chemotherapy(化疗）treatments，As a result of those treatments, he had lost all of his hair. I don't know about you, but I remember how I would have felt about that at his age —I would have felt awkward and ashamed.

    This young man's classmates willingly came to the rescue: all the boys in his grade asked their mothers if they could shave their heads so that Brian wouldn't be the only bald boy in the high school. There, on that page was a photograph of a mother shaving all of her sons' hair with the family looking on approvingly. And in the background, a group of similar bald young men.

    No, I don't despair about kids today.

根据短文内容，选择最佳答案，并将选定答案的字母标号填在题前括号内。

    When it was announced that Patrick Modiano had won the Nobel Prize in Literature on Oct.9, the Swedish Academy had not yet managed to reach the writer himself to tell him the news. as the Telegraph put it, “It was a curious case of missing personhood in an author whose career had been spent in searching others, within the confines (界限) of a single city.”

    Though the 69-year-old French author has had a successful writing career, only six of his books have been translated into English. One reason for this might be that “Modiano's storylines are as slim as the books themselves”, said the BBC.

    While most of Modiano's works don't run for hundreds of pages, they explore serious subjects. The author's signature themes are Germany's occupation during World War II and the evolution of Paris over the past century.

    Modiano's life has been greatly affected by Nazi Germany's occupation during the war, and his family's connections to it. According to New York-based newspaper Forward, his father survived the war dishonorably. When Paris's Jews were rounded up for deportation(驱逐)to concentration camps, the businessman did not join them but spent the time making money from deals with Nazis on the black market.

    “The novelist has a duty to record the traces of the people who were made to disappear,” French writer Clemence Boulouque, also an expert in Jewish Studies, told The New York magazine.

    In his more than three dozen novels, Modiano has returned again and to the same themes: Jewishness, the Nazi occupation, and loss of identity.

    Paris is another recurring(重复的)theme in Modiano's works .Most of his novels are set in the city , from the rich parts of downtown Paris to more remote suburbs where the characters try to live anonymous protect lives.

    Anne Ghisoli, the director of  Librairie Gallimard, a bookstore in Paris, concluded, “Modiano is a master of writing on memory and occupation, which haunt(萦绕)and inform his works. He is a chronicler(年代记录者)of  Paris ,its streets, and its present.”

Adult Education Courses

    Reading books and looking at pictures is great, but nothing facilitates (促进) learning like travel, especially for teenagers. Not only do they get to see a world beyond their neighborhood, they also get to experience it, feel it, taste it, hear it and better understand the world around them.

    After nearly four decades in the classroom and traveling the world, Phyllis Duvall Bailey knew this perhaps better than anyone else.

    Becoming involved in the work in AKA Sorority Inc in US, she worked to educate children about the United Nations. There was no doubt in Bailey's mind that the lessons would mean so much more if the students could see things for themselves.

    Starting in 2015, Bailey, 82, set out to take her students to the UN Headquarters in New York City to give them a "Window Seat to the World", and thus transformed them into global citizens.

    Indeed, it is a great opportunity to give students national and international exposure. Since Bailey saw the students as future leaders, she was desperate to expose them to the UN, its mission, its agendas (议程) and its supporting organizations.

    She decided to give $10, 000 of her own money to pay for the late June trip, enough to take 10 students aged 14-17 on a four-night stay in New York. There, they had guided tours of the UN Headquarters and the New York City Harbor (海港).

    It was Quenyaun Payne's first trip to the city and Taylor Sappington's second. Payne, 17, is a senior at Mceachem High School in the state of Georgia, US. Sappington, 15, is a junior at Therrell High School in Atlanta, Georgia, US. Both said their visit to the UN was inspiring.

    "I like not only how countries are working together but they're focused on common goals like global warming and keeping peace," Sappington said.

Payne commented, "The trip was amazing. I'm so thankful Mrs. Bailey made it possible."

    Actually, there are a lot of people grateful for the retired teacher's effort. The United Nations Association of Atlanta recently gave Bailey its Humanitarian Award, and the United Nations Association of the US-awarded her with the National Education Award.

    But Bailey wasn't looking for recognition or even gratitude. Over those four days in New York, she'd already felt it and seen it in the eyes of those 10 teenagers, Payne and Sappington included, who made the trip.

    "It has been a real joy to get to see and watch their reaction to new experiences," she said.

    What will restaurants look like in the future？What would your dinner taste like if a robot cooked it？A robot restaurant in Tianjin may give you the answers.

    Covering an area of over 400 square meters with a total of 112 seats, the X Future Restaurant is a robot restaurant opened in November 2018. The restaurant has amazed customers with its fully-automated(全自动的)technology, which covers every step of the dining experience, from ordering to cooking to serving the dishes and even taking payment.

    Entering the restaurant, one can order dishes by simply scanning(扫描)the QR codes on the table. There are over 40 choices of dishes. After taking the order, "robot cooks"prepare dishes using fixed time, temperature and ingredients designed by famous Chinese cooks.

    "As the cooking is controlled by a computer system, the taste and quality of dishes can be good, "said Li Xiaokui, manager of the X Future Restaurant.

    Robots also complete the delivery of dishes. Without following any designed route, the robot waiters serve meals thanks to automated driving technology, which helps each robot timely change its route when something is in the way.

These eye-catching technologies have received wide praise from customers. "The dishes taste surprisingly good. I couldn't believe that they were made by robots, especially dishes that were difficult to cook" one customer said. "The application of robots has increased our efficiency(效率)and cut down our costs, "Li said, "I think robot restaurants will develop fast and have a bright future. "