Exercise may help to safeguard the mind against depression through previously unknown effects on working muscles, according to a new study involving mice.

    Mental health experts have long been aware that even mild, repeated stress can contribute to the development of depression and other mood disorders in animals and people. Scientists have also known that exercise seems to cushion against depression. But precisely how exercise, a physical activity can lessen someone's risk for depression, a mood state, has been mysterious. So for the new study, researchers at the Karolinska Institute in Stockholm studied the brains and behavior of mice in a complicated and novel fashion.

    We can't ask mice if they are feeling cheerful or in low spirits. Instead, researchers have pictured certain behaviors that indicate depression in mice. If animals lose weight, stop seeking out a sugar solution when it's available — because, probably, they no longer experience normal pleasures — or give up trying to escape from the cold-water zone just freeze in place, they are categorized as depressed. And in the new experiment, after five weeks of frequent but low-level stress, such as being lightly shocked, mice displayed exactly those behaviors. They became depressed.

    The scientists could then have tested whether exercise blunts (延缓) the risk of developing depression after stress by having mice run first. But, frankly, from earlier research, they wanted to know how, so they bred pre-exercised mice. A wealth of earlier research by these scientists and others had shown that aerobic exercise, in both mice and people, increases the production within muscles of an enzyme (酶) called PGC-1alpha. The Karolinska scientists suspected that this enzyme somehow creates conditions within the body that protect the brain against depression. Then, the scientists exposed the animals, which without exercising, were in high levels of PGC-1alpha to five weeks of mild stress. The mice responded with slight symptoms of worry. But they did not develop depression. They continued to seek out sugar and fought to get out of the cold-water zone. Their high levels of PGC-1alpha appeared to make them depression-resistant. Finally, to ensure that these findings are relevant to people, the researchers had a group of adult volunteers complete three weeks of frequent endurance training, consisting of 40 to 50 minutes of moderate cycling or jogging. The scientists conducted muscle biopsies (活体检查) before and after the program and found that by the end of the three weeks, the volunteers' muscle cells contained substantially more PGC-1alpha than at the study's start. The finding of these results, in the simplest terms, is that “you reduce the risk of getting depression when you exercise,” said Maria Lindskog, a researcher at the Karolinska Institute.

    The Catskill Mountains are a year-round playground for outdoor enthusiasts and nature lovers. You will find a number of relaxing inns ready to meet your needs.

Caleb Street's Inn

    Located in the historic village of Catskill at the base of the mountains, Caleb Street's Inn was built in 1785. It provides a view of the garden and Catskill Creek or guests can step outside for a walk along the Hudson River. A full breakfast is served every morning. Each of the four Pet-friendly rooms offers a private bath and a view of the river and neighboring buildings. Hiking trails(小路), golf courses and historic sites are only a short drive away.

Winter Clove Inn

    Nature lovers can enjoy a pleasant location in the Northern Catskill Wilderness Preserve at Winter Clove Inn. With wood floors, each room has a private bath and air conditioning(空调). With active days of tennis, hiking or cross- country skiing ahead, guests don't have to go far for a breakfast, lunch or dinner beside the fireplace at inn's restaurant.

Windham House

    A former pub built in 1805, Christman's Windham House is the oldest inn continually operating in the Catskills. The 300 acres of grounds in the town of Windham include a tennis court, golf course, heated pool and a restaurant. Guests can relax on private balconies (阳台) overlooking a golf course and take their meals at Christman's Windham House Restaurant. The inn is less than 2 miles from the hiking trails of Windham Mountain.

Washington Irving In

    If you're looking for a mountain inn with a Victorian feel, Washington Irving Inn has much to offer. Furnished with antiques, each of the 15 rooms has a private bath. Free breakfast is served. Hikers are a short walk from Kaaterskill Falls and Hunter Mountain trails.

    Fear may be felt in the heart as well as in the head, according to a study that has found a link between the cycles of a beating heart and the chance of someone feeling fear.

    Tests on healthy volunteers found that they were more likely to feel a sense of fear at the moment when their hearts are contracting(收缩) and pumping blood around their bodies, compared with the point when the heartbeat is relaxed. Scientists say the results suggest that the heart is able to influence how the brain responds to a fearful event, depending on which point it is at in its regular cycle of contraction and relaxation.

    Sarah Garfinkel at the Brighton and Sussex Medical School said: “Our Study shows for the first time that the way in which we deal with fear is different depending on when we see fearful pictures in relation to our heart.”

The study tested 20 healthy volunteers on their reactions to fear as they were shown pictures of fearful faces. Dr Garfinkel said, “The study showed that fearful faces are better noticed when the heart is pumping than when it is relaxed. Thus our hearts can also affect what we see and what we don't see一and guide whether we see fear.”

To further understand this relationship, the scientists also used a brain scanner(扫描仪) to show how the brain influences the way the heart changes a person's feeling of fear.

“We have found an important mechanism by which the heart and brain ‘speak' to each other to change our feelings and reduce fear,” Dr Garfinkel said.

    “We hope that by increasing our understanding about how fear is dealt with and ways that it could be reduced, we may be able to develop more successful treatments for anxiety disorders, and also for those who may be suffering from serious stress disorder.”

    The impression you make at the beginning of an interview is very important. Employers often decide to hire someone in the first three minutes of the interview. They judge you by your appearance, attitude and manners.

    A friendly smile when you walk into the room is important. A smile shows a confident and positive attitude. When you introduce yourself, make eye contact with the interviewer. Some interviewers offer a handshake. Others don't.

    Try to be as natural as possible. But pay attention to your body language. The way you sit, walk, gesture, use your voice and show feelings on your face is all part of your body language. It makes the interviewer know how you feel about yourself and the situation you are in. Are you feeling positively about yourself？Your abilities? Your interest in the job？

    Speak clearly and loudly enough. Show interest and enthusiasm in your voice. When you speak, look at the interviewer. Also, don't say negative things about yourself, or former employer.

    Listen to questions carefully. If you don't understand a question, ask the interviewer to repeat or explain:

    "I'm sorry, but I didn't catch that."

    "Almost everyone is nervous in a job interview. Interviewers know that. They don't expect you to be totally calm and relaxed. But they expect you to try to control your nervousness. They expect you to show confidence in your ability to do the job.

    At the end of the interview, thank the interviewer for her or his time. It's a good idea to send a short thank-you letter right after the interview, or deliver it by hand.

    Phone the company if you have not heard anything after one week. Ask if they have made a decision about the job.

Good luck!

    My husband and I recently went to Disney World with our three children. We had a wonderful time. Besides, I experienced something that left a deep impression on me.

    Our children were excited about the attraction where children could drive the cars. They were so delighted that I decided to stand beside the track to get pictures of everyone as they drove past on the track.

    As I waited for them to drive by, I noticed a car with a father and his son who was about 7 years old. They rolled down the hill at the beginning, but suddenly the car stopped. The young driver looked nervous, "I can't do it." His father quietly said, "Yes, you can."

    "No. I can't!"

    "Yes, you can, son."

    The little guy was almost in tears, "I can't!" With deep patience, the father said, "Son, you can do this. I'm going to help you." A moment later, with the father helping his son, the two went smoothly (顺利地) on their way down the track.

    The scene brought tears to my eyes and it reminded (使想起) me of my dear father. Just like that little boy's dad, my father used to say the same words to me. Every time things got hard or when I experienced setbacks along the way, he would say, "Michelle, you can do this. I'm going to help you."

    Time and time again the words greatly encouraged me on the journey. I'm aware that I can't do things under my own power, but the words "Yes, you can" come beside me and give me wisdom and strength. As I benefited (受益) a lot from them, I often tell my children never to say "I can't" easily when they meet something difficult.

    Triple Olympic and world sprint(短跑) champion Usain Bolt of Jamaica said on Monday he expects years of fast feats to ease doping doubts in athletics and has no plans to play American football.

    Appearing on ESPN programs and in light-hearted races outside the television sport network's studios, Bolt said he feels he must prove himself to a skeptical sports world in the wake of past doping scandals(诽谤).

    "I have to prove myself to the world that you can run fast without it," Bolt said.

    Bolt cited the speeds he and countryman Asafa Powell and American Tyson Gay have achieved without positive doping tests.

    "We just (have to) continue to run fast," Bolt said. "In a couple of years everyone will continue to watch again and have less doubts."

    Bolt won gold in the 100m, 200 and 4x100 relay in world record times at last year's Beijing Olympics and last month in Berlin set world records of 9.58 seconds in the 100 and 19.19 in the 200 and helped a relay title in a World Championships treble.

    "I want to be a legend in the sport. For me it's all a focus on winning championships after championships," Bolt said.

    "I don't consider myself a legend. When I defend my titles I will consider myself a legend."

    Bolt's defending of World and Olympic gold should be the feature attraction of the 2011 IAAF World Championships in Daegu, South Korea, and the 2012 London Olympics.