Apple Seeds

Circulation (发行量)：1 Year, 9 Issues

Cover Price:$44.55

Price for You:$33.95

Product Description:Apple Seeds is an award winning magazine filled with stories for kids aged from 7 to 9. The cover is very soft, providing durability that allows each issue to be enjoyed for many years to come. Besides, there is a big surprise for you —-- it's being sold at a more favorable discount than usual.

Better Life

Circulation: 1 Year, 12 Issues

Cover Price: $44.55

Price for You:$15.00

Product Description: Designed for those who have a strong interest in personal lifestyle. Better life is an America's complete home and family service magazine. If offers help with food, recipes, decorating, building, gardening, family health, money management and education.

Humor Times

Circulation:1 Year, 12 Issues

Cover Price: $36.00

Price for You: $ 11.95

Product Description:Humor Times is for those who love to laugh! Full of cartoons and humor columns, it shows up in your mailbox once a month and keeps you smiling all year round! In today's world, you need a reason to laugh. So let's find it in Humor Times.

News China

Circulation: 1 Year, 12 Issues

Cover Price:$ 47.88

Price for You:$19.99

Product Description: News China is the English edition of China Newsweek. The magazine covers the latest Chinese domestic news in politics, society, environment, culture, sports and travels, etc. It is the first comprehensive news magazine for readers interested in China.

    Here is an astonishing and significant fact: Mental work alone can't make us tired. It sounds absurd. But a few years ago, scientists tried to find out how long the human brain could labor without reaching a stage of fatigue(疲劳). To the amazement of these scientists, they discovered that blood passing through the brain, when it is active, shows no fatigue at all! If we took a drop of blood from a day laborer, we could find it full of fatigue toxins(霉素) and fatigue products. But if we took blood from the brain of an Albert Einstein, it would show no fatigue toxins at the end of the day.

    So far as the brain is concerned, it can work as well and swiftly at the end of eight or even twelve hours of efforts as at the beginning. The brain is totally tireless. So what makes us tired?

    Some scientists declare that most of our fatigue comes from our mental and emotional(情感的) attitudes. One of England's most outstanding scientists, J. A. Hadfield, says, “The greater part of the fatigue from which we suffer is of mental origin. In fact, fatigue of purely physical origin is rare.” Dr. Brill, a famous American scientist, goes even further. He declares, “One hundred percent of the fatigue of a sitting worker in good health is due to emotional problems.”

    What kinds of emotions make sitting workers tired? Joy? Satisfaction? No! A feeling of being bored, anger, anxiety, tenseness, worry, a feeling of not being appreciated—those are the emotions that tire sitting workers. Hard work by itself seldom causes fatigue. We get tired because our emotions produce nervousness in the body.

    Science Museum, London

    Runs: Until 5 May

    Price: £7

    Exhibition about the Large Hadron Collider which uses theatre and video, as well as handmade works to recreate the experience of the real place and show the work behind the discovery of the Higgs 、 boson. Well worth it for anyone studying physics or simply interested.

    Weston Park Museum, Sheffield

    Runs: Until 5 May Price: Free for students

    Underneath the 1960s-built Castle Market in Sheffield, there are the remains of a historical castle. Now that the market is being moved, there has been a sudden growth in interest in the old castle.

    Seacity Museum, Southampton

    Runs: Continued

    Price: Entrance to the museum is £4.50 for students

    Explores the Titanic disaster and its effect on Southampton, where more than five-hundred families lost a family member to the disaster. The exhibition recreates the sights and sounds of 1912 Southampton and ends ill the Disaster Room, where a series of events from the moment of the Titanic hit the iceberg are explored using powerful oral description from survivors.

    The Guildhall, Leicester

    Runs: Until 1 June

    Price: Free

    This exhibition tells the history of King Richard III and of the search for his lost remains, eventually found underneath a car park two years ago. The exhibition can give visitors a rounded view of the life of the king and how he was discovered. Great for history students.

    Many experts say that Billy Wilder changed the history of American movies. He is often called the best movie maker Hollywood has ever had, known for making movies that offered sharp social comment.

    Between the 1930s and the 1980s, Billy Wilder made almost fifty movies. During that time he received more than twenty nominations from the Academy of Motion Picture Arts and Sciences. He won six of the Oscar awards. His movies have been seen by people around the world, like “Sunset Boulevard”, “Some Like It Hot”, “The Lost Weekend”, “The Apartment”, and “The Seven Year Itch”.

    Samuel Wilder was born in 1906 in the former Austro-Hungarian Empire. His mother had enjoyed spending several years in the United States when she was young. So she called him Billy because she thought it sounded American. Billy Wilder started law school in Vienna, Austria. Then he decided not to become a lawyer. Instead, he began reporting for a Vienna newspaper. By the 1920s, he was writing movies in Germany.

    However, the Nazis had risen to power in the nation. Wilder was Jewish, and he recognized that he had no future in Nazi Germany. In 1933, he went to Paris. There he directed a movie for the first time. It was called “The Bad Seed”. Then he received word that producers in the United States had accepted one of his scripts. Billy Wilder left Europe for America.

    Billy Wilder had only eleven dollars when he arrived to settle in the United States in 1934. He decided to live in the center of American movie making, Hollywood, California. Then he formed a writing team with Charles Brackett. The two writers created many successful films together. Wilder always praised this man as a friend and teacher whose humor and expert direction greatly influenced his work.

    In his love stories, Billy Wilder did not follow the Hollywood tradition of sweet boy-meets-girl situations. He had an unusual way of showing relations between men and women. Wilder died in March, 2002. A current Hollywood producer said: “Billy Wilder made movies that people will never forget.”

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

    If American waterways had ever been voted on the yearbook, the Buffalo River could easily have been named Ugliest. It could be hard to find hope there. It took decades for public perception of the river to shift. But activist citizens, who collaborated with industry, government, and environment groups never gave up on their polluted river—the Buffalo River gradually went from being considered a lost cause to a place worth fighting for. And by now the cleaned—up water is one of Buffalo'S biggest attractions.

    By the 1960s, the river was seen as one of the worst sources of pollution pouring into the Great Lakes. The Buffalo River had caught fire many times. The surface had an oily layer, and any fish caught there were not eatable.

    The waterway's fate started shifting in the mid-1960s. Stanley Spisiak was a local Polish—American jeweler by day, but by evening he was the kind of guy who'd chase down dumpers(垃圾车)he spotted on the Buffalo River. By 1966 he found himself winning the National Wildlife Federation's "Water Conservationist of the Year" award. And before long he got a nickname:" Mr. Buffalo River. "But there was only so much he could do—the river was still declared biologically dead in 1969.

    Jill Spisiak Jedlicka is his great-grandniece. She picks up where he left off by directing the river's protector organization, Buffalo Niagara Waterkeeper. Professor Schneekloth and seven friends founded the organization as an all-volunteer nonprofit in 1989, after organizing the first river cleanup that year. Today the group employs 27 full-time workers and has helped oversee the Buffalo River's $100 million restoration.

    So far, the Buffalo River's water quality has restored, but it is still an ongoing issue, as sewage(污水)can overflow into the river after storms. Habitat restoration continues as well; fish and plantings are still being sampled to measure how well it's gone.