This contest from the Winchester Poetry Festival is intended for “surprise and delight”. However, don't try to surprise and delight them with a short story or a photo of your cat dancing in a Tutu. Stick to a poem of up to 40 lines.

    Closing: Quarterly.

    Prizes: £1,000, £500, £250.

    Entry Fee: £5.

    Starts Theatre One-Act Play Competition

    This annual contest from Strerts Theatre in Cornwall is for plays for up to four adult actors, with a running time of between 25 and 35 minutes. Plays can be on any theme; you need to be 18 or over to enter.

    Closing: Annually.

    Prizes: £100 plus performance of your play in Sterns Studio.

    Entry Fee: £7.

    Artificium Short Stories & Poetry Prizes

    This one from Artificium, a journal of new fiction and poetry, has two categories: Short Stories and In Brief. The former is for stories of between 2,000 and 8,000 words in any genre（体裁）. The latter is for poetry of between 500 and 1,000 words.

    Closing: End of each month.

    Prizes: £200, £100, £50.

    Entry Fee: £5 for one, £9 for two.

    PENfro Open Poetry Competition.

    This contest from the PENfro Book Festival is for poems of up to 40 lines on any subject and in any style. Costa Award winning poet Jonathan Edwards, whose taste in poetry is broad-ranging, will be judging.

    Closing: End of each month. Prizes: £300, £100, £75. The top ten winners will be invited to read their works at a spoken word event at which Jonathan Edwards will present the prizes.

    Entry Fee: £4.

    Drug companies have spent billions of dollars searching for therapies to reverse or significantly slow Alzheimer's disease, but in vain. Some researchers argue that the best way to make progress is to create better animal models for research, and several teams are now developing mice that more closely imitate how the disease destroys people's brains.

    The US National Institutes of Health (NIH), the UK Dementia Research Institute and Jackson Laboratory (JAX) - one of the world's biggest suppliers of lab mice - are among the groups trying to genetically design more suitable mice. Scientists are also exploring the complex web of mutations(突变) that influences neurological (神经学的) decline in mice and people.

    "We appreciate that the models we had were insufficient. I think it's sort of at a critical moment right now." says Bruce Lamb, a neuro-scientist at Indiana University ~ho directs the NIH-funded programme.

    Alzheimer's is marked by cognitive impairment(认知损伤) and the build-up of amyloid-protein plaques (淀粉样蛋白块) in the brains of people, but the disease does not occur naturally in mice. Scientists get around this by studying mice that have been genetically modified to produce high levels of human amyloid protein. These mice develop plaques in their brains, but they still do not display the memory problems seen in people.

    Many experimental drugs that have successfully removed plaques from mouse brains have not lessened the symptoms of Alzheimer's disease in people. One focused stumble came last month, when three companies reported that their Alzheimer's drugs had failed in large, late-stage clinical trials. Although the drugs successfully blocked the accumulation of amyloid protein in mice, they seemed to worsen cognitive decline and brain shrinkage in people.

    The drive for better mouse models comes as genomics studies are linking the most common form of Alzheimer's to dozens of different genes. This diversity suggests that each case of the disease is caused by a different combination of genetic and environmental factors. "There is no single Alzheimer's disease," says Gareth Howell, a neuro-scientist at Jackson Laboratory (JAX) in Bar Harbor, Maine.

    Howell argues that scientists' reliance on lab mice with only a few genetically engineered mutations might have limited research. His own work suggests that in mice, just as in people, genetic diversity plays a part in determining how Alzheimer's develops.

    “That one looks just like a sheep! And look over there. That one looks like a horse!” Do you remember lying on your back in a grassy field on a summer afternoon, discovering the soft shapes in the clouds in the sky? Those were the good old days when you could see anything and everything in the clouds.

    But now people look at the sky and see clouds in the shape of a motor company's advertising logo (商标),or a message inviting them to go out and buy a certain brand (品牌) of beer. These cloud pictures are not products of their imaginations. Instead, they are produced by a machine. These new floating advertisements are called Flogos; the name stands for “floating logos.” They' re made from a mixture of soapy foam (泡沫)and a lighter-than-air gas such as helium, and they can be made into different sizes and shapes depending on the advertisement.

    Flogos can last up to an hour if weather conditions are good, and they can fly several kilometers high. Advertisers can rent a Flogo machine for$2,500 a day. The set-up is normally performed within 1 to 2 hours, and it will release four Flogos per minute. Advertisers can fill the air with any shape or message they want.

    Some people are worried that the Flogos might not be pollution-free. However, the Flogo's inventor insists that the soap he uses is natural, and that a Flogo just dissipates in the air, leaving nothing behind. Though it may be true that Flogos are environmentally friendly, some people believe that the natural clouds in our memory may be replaced by man-made ones. They are afraid that soon there will be nowhere left where their imaginations can float freely.

    If you are invited to a wedding, baby shower or other celebrations, you will be expected to bring a gift. Unless you know the host very well, the gift should be modest in value, about $25 or so.

    For a wedding, the bride will have "registered (登记)" at one or two local department stores，indicating the items she prefers. You can buy the couple a gift that isn't listed , but most people buy something listed on the registry (记录簿). If you buy an item listed on the registry, be sure to tell the store that you are doing this, so that the couple doesn't receive duplicate (重复的) gifts. For a baby shower, bring a gift appropriate for a new born baby.

    If you wish to give a gift when you leave to return to your country, the best gift   is something unique to your country. It does not need to be especially valuable or rare. Possibilities include a book about your country, an inexpensive piece of handicraft( 手工艺品)or art, or something else that reflects your culture. If the children collect coins and stamps, they would be very pleased with a set of your country's coins or a selection of stamps from your country.

    If you owe a debt of deep gratitude to an American host family, a common way of repaying it is to take the family to a form of entertainment, such as a baseball, basketball, or a good restaurant.

    Gift giving is not as important in America as it is in other countries, so there is nothing wrong with not giving a gift. If you need help, talk to a salesperson at a department store. Tell them about the person who will be receiving the gift and the reason for the gift, and they will help you find something appropriate.

    It was at least two months before Christmas when nine-year-old Rose told her father and me that she wanted a new bicycle.

As Christmas drew nearer, her desire for a bicycle seemed to fade—or so we thought, as she didn't mention it again. We bought the latest fashionable Baby Sitter's Club dolls, a holiday dress and some beautiful story books. Then, much to our surprise, on December 23rd, she proudly announced that she "really wanted a bike more than anything else."

    It was just too late, what with all the details of preparing Christmas dinner and buying last-minute gifts. We could only think of the bicycle and the disappointment of our child. "What if I make a little bicycle out of clay and write a note that she could trade the clay model in for a real bike?" Her dad asked. The theory, of course, being that since that is a high-ticket item and she is "such a big girl", it would be much better for her to pick it out. So he spent the next five hours painstakingly working with clay to make a tiny bike.

    Three hours later, on Christmas morning, we were excited for Rose to open the little heart-shaped package with the beautiful red and white clay bike and the note. Finally, she opened it and read the note aloud.

    She looked at me and then at her dad and said, "so does this mean that I trade in this bike that Daddy made me for a real one?"

    Beaming, I said, "Yes."

    Rose had tears in her eyes when she replied, "I could never trade in this beautiful bicycle that Daddy made me. I'd rather keep this than get a real bike."

    At that moment, we would have moved heaven and earth to buy her every bicycle on the planet!

    A while back I caught a news report on something called couch surfing and the network of trusting souls who make this phenomenon possible. They offer to put up travelers free of charge and help them on their ways. At first, it sounded unbelievable. I mean, inviting strangers into one's home for one or two nights? Give me a break.

    However, I was intrigued. I decided to find it out. The only way to truly learn about this phenomenon was to dive in. So I planned a trip to Finland, a country I've always wanted to explore. I would couch surf at every stop there.

    If ever any anxiety existed when stepping into the unknown, it disappeared when my first host met me at the train station. Ari looked like my idea of a typical Finn: tall and blue-eyed. Finns were also supposed to be famously reserved (寡言少语的). Ari was anything but. He was a live wire, giving me a warm welcome and walking with me to his apartment, where he showed me the sleeper sofa, served me tea, and engaged me in warm conversations. He also handed me a key to come and go as I pleased.

    If this was what couch surfing was all about—trust and friendship—then I had gotten off to a good start. As I boarded my next train to continue my journey, I began to think about this couch-surfing idea. What encouraged these people to open their homes to strangers? I concluded that there was a desire to lend a hand to like-minded folks who might enrich their own lives.

    Seven cities in 14 days. Seven hosts. Seven new friends. If couch surfing taught me anything, it's this: Most people are good and generous. Where will couch surfing take me next? Who knows? But I can't wait to find out.