Exercise may help to safeguard the mind against depression(沮丧) through previously unknown effects on working muscles, according to a new study involving mice.

    Mental health experts have long been aware that even mild, repeated stress can contribute to the development of depression and other mood disorders in animals and people. Scientists have also known that exercise seems to cushion against depression. But precisely how exercise, a physical activity can reduce someone's risk for depression, a mood state, has been mysterious. So for the new study, researchers at the Karolinska Institute in Stockholm studied the brains and behavior of mice in a complicated and novel fashion.

    We can't ask mice if they are feeling cheerful or in low spirits. Instead, researchers have pictured certain behaviors that indicate depression in mice. If animals lose weight, stop seeking out a sugar solution when it's available — because, probably, they no longer experience normal pleasures — or give up trying to escape from the cold-water zone just freeze in place, they are categorized as depressed. And in the new experiment, after five weeks of frequent but low-level stress, such as being lightly shocked, mice displayed exactly those behaviors. They became depressed.

    The scientists could then have tested whether exercise blunts (延缓) the risk of developing depression after stress by having mice run first. But, frankly, from earlier research, they wanted to know how, so they bred pre-exercised mice. A wealth of earlier research by these scientists and others had shown that aerobic exercise, in both mice and people, increases the production within muscles of an enzyme (酶) called PGC-1alpha. The Karolinska scientists suspected（怀疑） that this enzyme somehow creates conditions within the body that protect the brain against depression. Then, the scientists exposed the animals, which without exercising, were in high levels of PGC-1alpha to five weeks of mild stress. The mice responded with slight symptoms of worry. But they did not develop depression. They continued to seek out sugar and fought to get out of the cold-water zone. Their high levels of PGC-1alpha appeared to make them depression-resistant（抵抗的）. Finally, to ensure that these findings are relevant to people, the researchers had a group of adult volunteers complete three weeks of frequent endurance training, consisting of 40 to 50 minutes of moderate cycling or jogging. The scientists conducted muscle biopsies (活体检查) before and after the program and found that by the end of the three weeks, the volunteers' muscle cells contained substantially more PGC-1alpha than at the study's start.

    The finding of these results, in the simplest terms, is that “you reduce the risk of getting depression when you exercise,” said Maria Lindskog, a researcher at the Karolinska Institute.

    A Guide to the University

    Food

    The TWU Cafeteria is open 7am to 8pm. It serves snacks(), drinks, ice cream bars and meals. You can pay with cash or your ID cards. You can add meal money to your ID cards at the Front Desk. Even if you do not buy your food in the cafeteria, you can use the tables to eat your lunch, to have meetings and to study.

    If you are on campus in the evening or lat at night, you can buy snacks, fast food, and drinks in the Lower Café located in the bottom level of the Gouglas Centre. This area is often used for entertainment such as concerts, games or TV watching.

    Relaxation

    The Globe, located in the bottom level of McMillan Hall, is available for relaxing, studying , cooking, and eating. Monthly activities are held here for all international students. Hours are 10 am to 10 pm, closed on Sundays.

Health

    Located on the top floor of Douglas Hall, the Wellness Centre is committed to physical, emotional and social health. A doctor and nurse is available if you have health questions or need immediate medical help or personal advice. The cost of this is included in your medical insurance. Hours are Monday to Friday, 9am to noon and 1;00 to 4;30pm.

    Academic Support

    All students have access to the Writing Centre on the upper floor of Douglas Hall. Here, qualified volunteers will work with you on written work, grammar, vocabulary, and other academic skills. You can sign up for an appointment on the sign-up sheet outside the door two 30 –minute appointments per week maximum. This service is free.

    Transportation

    The TWU Express is a shuttle service. The shuttle transports students between campus and the shopping centre, leaving from the Mattson Centre. Operation hours are between 8am and 3pm. Saturdays only. Round trip fare is $1.

    In the professional or career world, a gap year is when one stops their formal work life to pursue other interests. However, today gap year refers mostly to a year taken between high school and college.

    During this gap year, American students engage in advanced academic courses, extra-academic courses and non-academic courses, such as yearlong pre-college math courses, language studies, learning a trade, art studies, volunteer work, travel, internships(实习), sports and more.

    British and European students, however, take a much more vacation style approach to the “Gap Year” by generally working for 3-6 months and then traveling throughout the globe for the remaining time before college begins. This is intended to expand the mind, personal confidence, experiences, and interests before college.

    Let's look at the gap year in the following countries:

Denmark

    Denmark has tried to limit the number of students who take a year out, punishing students who delay their education to travel abroad or work full-time. In 2015, it was announced that fewer students than before had taken a year out.

India

    In India, the practice of taking time out after high school education, popularly called a drop year, has been on a quick rise in recent years, primarily students deciding to enroll in coaching institutions to prepare themselves for rigorous(严格的)college entrance examinations. However, using that year for travel is still not common.

Republic of Korea

     In republic of Korea, gap year is defined as time for the youth to think about directions of their lives by going through gap year programs such as voluntary activity, career exploration, education, having a relationship, internship and enterprise while he/she pauses studying.

United Kingdom

    In the United Kingdom a year out is a common choice before university, again to travel or volunteer, gaining life experience. All universities seem to welcome gap year applicants, no different from going straight to university from previous education.

    For more than fifty years, a worker was forced to sit on the back of a truck and slowly drop plastic barriers（障碍） to set out lanes（车道）on the Golden Gate Bridge in San Francisco. Every day, their direction changes to control the traffic, meaning an employee had to go through the difficult task every twenty-four hours.

    But a new piece of machinery means the work can be completed in a matter of minutes. A new “zipper truck” has been introduced. The vehicle lays and moves a lane barrier as it drives over the bridge. Last weekend, the bridge was closed so the new safety barrier, designed to reduce the dangers of head-on crashes, could be set up.

    For the longest period in its nearly eighty-year history, the bridge was closed early Saturday to all but walkers, cyclists and buses to set up the barriers on the 1.7-mile bridge. A survivor of a 2008 head-on crash on the bridge spoke Sunday from a wheelchair to help introduce the new barrier, made of steel-clad concrete（铜包混凝土）blocks that can move across the bridge's six lanes to meet traffic needs.

    Gr. Grace Dammann pushed for a safer barrier since becoming unable to walk after the accident. She said she decided to drive near the middle of the bridge, which was called the “suicide（自杀）lane”, because she and her daughter were running late. Brian Clark, who was driving in the opposite direction, had just learned his father had cancer. “He suddenly lost control of the wheel, crossed over and hit my car,” Dammann said.

    She said she and Clark became friends as they persuaded（说服）the government to use the MYM30 million barrier. “I am so thankful,” said Dammann, who came to the ceremony with Clark.

    “Clark and I thank you.”

    We walked in so quietly that the nurse at the desk didn't even lift her eyes from the book. Mum pointed at a big chair by the door and I knew she wanted me to sit down. While I watched mouth open is surprise, Mum took off her hat and coat and gave them to me to hold. She walked quietly to the small room by the lift and took out a wet mop. She pushed the mop past the desk and as the nurse looked up, Mum nodded and said, "Very dirty floors. "

    "Yes, I'm glad they've finally decided to clean them, "the nurse answered. She looked at Mum strangely and said, "But aren't you working late?"

    Mum just pushed harder, each swipe(拖一下)of the mop taking her farther and farther down the hall. I watched until she was out of sight and the nurse had turned back to writing in the big book.

    After a long time Mum came back. Her eyes were shining. She quickly put the mop back and took my hand. As we turned to go out of the door, Mum bowed politely to the nurse and said, "Thank you."

    Outside, Mum told me, "Dagmar is fine. No fever. "

    "You saw her, Mum?"

    "Of course. I told her about the hospital rules, and she will not expect us until tomorrow. Dad will stop worrying as well. It's a fine hospital. But such floors! A mop is no good. You need a brush."

    I'll never forget the day when Mary came into my office and said, I am too old to learn how to use a computer. I shook my head. Here was a woman who had raised 6 children and who had made great progress in her career telling me that she was too old to learn something new. I told her that I always believed people were never too old to learn.

    Mary followed my advice and did learn how to use the computer. Now, she is retired and leading a very active life volunteering in her community(社区), using her computer skills and helping anyone that needs help.

    When she was in her sixties, one day she called me and said she had played the piano for others all her life, and now she was going to plan to make a CD of her own. My mind flashed back to the day when she told me she was too old to learn. You can imagine my surprise and delight.

    To produce the CD, she had a lot of things to learn. It was not just sitting at the piano and playing. She had to research the songs, learn about copyright(版权), and learn about marketing. It was pretty amazing for someone who once said she was too old to learn. And finally she made it. Now she has her own CD-Mixed Blessings.

    Most of you probably have heard about some people who have gone back to university in their seventies and have also graduated. They are on their way again to charging themselves with a new skill and a new attitude towards life. The point is you are unable to learn anything at any age if you believe you are too old. On the contrary, you can achieve anything at any age if you believe you can.