If you are a fruit grower—or would like to become one—take advantage of Apple Day to see what's around. It's called Apple Day but in practice it's more like Apple Month. The day itself is on October 21, but since it has caught on, events now spread out over most of October around Britain.

Visiting an apple event is a good chance to see, and often taste, a wide variety of apples. To people who are used to the limited choice of apples such as Golden Delicious and Royal Gala in supermarkets, it can be quite an eye opener to see the range of classical apples still in existence, such as Decio which was grown by the Romans. Although it doesn't taste of anything special, it's still worth a try, as is the knobbly(多疙瘩的) Cat's Head which is more of a curiosity than anything else.

There are also varieties developed to suit specific local conditions. One of the very best varieties for eating quality is Orleans Reinette, but you'll need a warm, sheltered place with perfect soil to grow it, so it's a pipe dream for most apple lovers who fall for it.

       At the events, you can meet expert growers and discuss which ones will best suit your conditions, and because these are family affairs, children are well catered for with apple-themed fun and games.

Apple Days are being held at all sorts of places with an interest in fruit, including stately gardens and commercial orchards(果园). If you want to have a real orchard experience, try visiting the National Fruit Collection at Brogdale, near Faversham in Kent.

    In the movie Alice in Wonderland, Alice comes across a Cheshire cat and asks the cat which road she should take. The cat responds, “Well, that depends on where you're trying to get to.” Alice replies, “I don't know.” The cat responds, “Then any road will do.”

    You see, knowing where you're going increases your chances dramatically of getting there, and there is no better way of “GETTING THERE” than setting your goals for the upcoming year. Think of your goals as destinations and the action steps as your GPS guiding and directing you. If you are like many other people, for years you have resisted the need to set goals and even laughed at the thought that setting goals and，even more importantly, committing them to writing have positive effects on your life. However, a closer look might convince you that setting goals is a sensible thing to do.

    In 1979, a class of Harvard MBA students was asked: Have you set clear, written goals for your future and made an action plan to accomplish them? The following will astonish you. Only 3 percent of the class had written goals and a plan in place, 13% just had goals, and an amazing 84% had no specific goals at all.

    Ten years later the numbers of the class were interviewed once again and the following results will no doubt give the reason for our setting goals. The findings were that the 13% who had goals were earning, on average, twice as much as the 84% who had no goals at all. And the 3 percent who had clear, written goals with a plan to achieve them were achieving ten times as much as the entire 97% combined.

    Goal setting will increase your chances of arriving successfully at your destination. Remember, always set SMART goals. Goals should be: Specific, Measurable, Attainable, Relevant, and Time-bound!

    Let us all raise a glass to AlphaGo and the advance of artificial intelligence. AlphaGo, DeepMind's Go-playing AI, just defeated the best Go-playing human, Lee Sedol. But as we drink to its success, we should also begin trying to understand what it means for the future.

    The number of possible moves in a game of Go is so huge that in order to win against a player like Lee. AlphaGo was designed to adopt a human—like style of gameplay by using a relatively recent development--deep learning. Deep learning uses large data sets," machine learning" algorithms （计算程序） and deep neural networks to teach the AI how to perform a particular set of tasks. Rather than programming complex Go rules and strategies into AlphaGo DeepMind designers taught AlphaGo to play the game by feeding it data based on typical Go moves. Then, AlphaGo played against itself, tirelessly learning from its own mistakes and improving its gameplay over time. The results speak for themselves.

    Deep learning represents a shift in the relationship humans have with their technological creations. It results in AI that displays surprising and unpredictable behaviour. Commenting after his first loss, Lee described being shocked by an unconventional move he claimed no human would ever have made. Demis Hassabis, one of DeepMind's founders, echoed this comment:"We're very pleased that AlphaGo played some quite surprising and beautiful moves."

    Unpredictability and surprises are—or can be—a good thing. They can indicate that a system is working well, perhaps better than the humans that came before it. Such is the case with AlphaGo. However, unpredictability also indicates a loss of human control. That Hassabis is surprised at his creation's behaviour suggests a lack of control in the design. And though some loss of control might be fine in the context of a game such as Go, it raises urgent questions elsewhere.

    How much and what kind of control should we give up to AI machines? How should we design appropriate human control into AI that requires us to give up some of that very control? Is there some AI that we should just not develop if it means any loss of human control? How much of a say should corporations, governments, experts or citizens have in these matters? These important questions, and many others like them, have emerged in response, but remain unanswered. They require human, not human - like, solutions.

    So as we drink to the milestone in AI, let's also drink to the understanding that the time to answer deeply human questions about deep learning and AI is now.

    We work with Cambridge County Council's Participation Team to create opportunities for young people to visit the University and learn more about it. The following events are scheduled for the 2019/2020 academic year.

    Superstar workshops

    12 engaging workshops are planned for young people aged 7 to 11. These half-day visits will be held throughout the year, at times when young people are not at school. If participants complete 8 of the 12 workshops, they will be awarded the nationally recognized Superstar Crest Award.

Please note, workshops will only run if we have a sufficient number of attendees (usually around 3+ participants).

    Explore University Days

    Explore University Days are for young people aged 12-15. Participants visit the University for two days and engage with a range of university-related workshops, and other fun activities.

Previous participants have engaged with the following:

    Visited the Sports Centre

    Took part in a Neuroscience workshop

    Enjoyed a two-course meal at a University College

    Dates will be confirmed in early December 2019, and a schedule for event will follow in the New Year.

    Events for post-16 students

    If you are studying for your post-16 qualifications and are considering applying for Cambridge or would like to find out more about a specific subject, the following events might be for you:

    University and College Open Days

    Subject Master classes

    Cambridge Science Festival

    The largest genetic study of mosquitoes has found their ability to resist insecticides(杀虫剂) is evolving rapidly and spreading across Africa, putting millions of people at higher risk of contracting malaria(疟疾).

British scientists who led the work said mosquitoes' growing resistance to control tools such as insecticide-treated bed nets and insecticide spraying, which have helped cut malaria cases since 2000, now threatens "to disturb malaria control" in Africa.

    "Our study highlights the severe challenges facing public efforts to control mosquitoes and to manage and limit insecticide resistance," said Martin Donnelly of the Liverpool School of Tropical Medicine, who worked on the study with a team from Britain's Wellcome Trust Sanger Institute.

    Latest World Health Organization (WHO) data show that 216 million people were infected last year with the malaria parasite(寄生虫), which is transmitted by blood-sucking Anopheles mosquitoes. The disease killed 445,000 people in 2016, and the majority of them were children in sub-Saharan Africa.

    To understand how mosquitoes are evolving, the researchers sequenced the DNA of 765 wild Anopheles mosquitoes taken from 15 locations across eight African countries. Their work, published in the journal Nature on Wednesday, created the largest data resource on natural genetic variation for any species of insect.

    Analyzing the data, the scientists found that the Anopheles gamblae mosquitoes(冈比亚疟蚊)were extremely genetically diverse compared with most other animal species. This high genetic diversity enables rapid evolution, they said, and helps to explain how mosquitoes develop insecticide resistance so quickly.

    The data also showed the rapid evolution of insecticide resistance appeared to be due to many previously unknown genetic variants(变体)within certain genes. The scientists said these genetic variants for insecticide resistance were not only emerging independently in different parts of Africa, but were also being spread across the continent by mosquito migration.

    Michael Chew, an expert at Britain's Wellcome Trust global health charity which helped fund the research, said the finds underlined the importance of pushing scientific research ahead to control malaria.

Global efforts to control malaria through effective vaccine, insecticides and the best drug combinations require urgent, united action by scientists, drug companies, governments and the WHO.

    Women may have good reason to drink coffee as much as they like. According to recent research, women who drank three or more cups of coffee a day were 30 percent less likely to have memory decline at age 65 than whose who drank one cup or less daily. And the benefit increased with age. Women over age 80 who drank three or more cups of coffee a day were about 70 percent less likely to have memory decline than those who drank one cup or less, the researchers said.

    Caffeinated tea had the same effect in the women, the study found, although more was needed to get the same caffeine boost. "Count roughly two cups of tea for a cup of coffee," said study leader Karen Ritchie of INSERM, the French National Institute for Health and Medical Research.

    But the researchers didn't find a similarly protective effect in men, although other studies have found a benefit to males.

    How might caffeine help ward off cognitive decline? "It is a cognitive stimulant." said Ritchie. "It also helps to reduce levels of the protein called beta amyloid in the brain" she said, "whose accumulation is responsible for Alzheimer's disease but which also occurs in normal aging."

    Ritchie said she wasn't sure why men in the study didn't benefit from caffeine. "Our hypothesis is that either women metabolize caffeine differently than men, or there may be an interaction of the caffeine with the sex hormones," she said.

    The French study confirms previous research, said William Scott, professor of medicine at the University of Miami Miller School of Medicine, who has researched caffeine's beneficial effects against Parkinson's disease, also a neurodegenerative disorder.

    As for caffeine only protecting women, Scott noted that just 2,800 of the 7,000 study participants were men, and the results might have differed if more men were included.

    A study published in February in the European Journal of Clinical Nutrition looked at 676 healthy men and found that regular coffee drinkers had a lower rate of cognitive decline over a 10-year follow-up than those who didn't drink coffee. Those who drank three cups daily had the least signs of decline.

    Both Scott and Ritchie agreed that more study is needed. Ritchie's research will next look at the relationship between caffeine and Alzheimer's.