Your New Year's plan to move more is one of the toughest to stick to, and a group of scientists working with obese(过度肥胖的) mice think they're starting to understand why

    Rather than our sedentary(久坐的) lives causing weight gain, says Alexxai Kraviz, the National Institutes of Health neuroscientist who led the study, changes in brain chemistry after we start gaining weight affect our capacity to move.

    “Obses mice can move just fine,” says Kravitz, who published the work with his team in Cell Metabolism “They just don't.”

    What Kravitz's team found is that the activity of a particular dopamine(多巴胺) receptor linked to movement goes down as mice gain weight on a high-fat diet. So the nice slow down and they move less. And when the researchers restored the activity of that dopamine receptor—DR2—the mice started moving more, even though they were still obese. The team also saw that lean mice missing the DR2 receptor acted like obese mice. This is the target, says Kravitz—restoring that dopamine receptor function. “Maybe 20 or 30 years down the road, we could do that in people,” he says.

    And there is one more thing: The scientists fed normal mice and the mice lacking DR2 the same high-fat diet. Both sets of mice gained weight at the same rate.

    Kravitz says this is important because mice lacking DR2 move less from the get-go, whereas a normal mouse takes a little time to start seeing that dopamine receptor-related loss of exercise. The ability to exercise seems to be disconnected from weight gain, he says.

    “Exercise is a healthy thing to do, but its impact on weight loss has been exaggerated,” he says. “We have to be realistic about the size of the effect of exercise on weight, as opposed to health benefits.”

    Still, before you abandon your New Year's exercise plan, keep in mind that this study was done using a high-fat diet, and not the normal calorie restriction that people maintain when they diet.

    That's a big drawback to the work, says Vicki Vieira-Potter, a University of Missouri physiologist not involved in the study.

    “They feed the mice with high-fat diet, it damages the receptor, and that decreases activity. Those who plan to lost weight should remember high-fat diet is a nice way to cause obesity in the lab, but it's not the same as the normal situation of obesity,” she says.

    Sine also says that a lot of the weight gain in the mice came after they stopped moving around, which indicates that the loss of movement did impact obesity.

    Both are so much related to each other. And both are so dissimilar! What are the differences between friendship and love? Is platonic (理想的) friendship possible between persons of opposite sex? Let us try and understand.

    What is friendship? Why do we call a person our friend? When do we call someone a very good friend? If we care for a person, if we are always ready to help that person and if we share most of our thoughts with a person, they are our good friends. We can always count upon our good friends in an emergency. We are always sure that our friend will understand why we acted in a certain way. We need not explain anything to our very good friends. The friendship is so deep and the relationship is so close.

    What about love? In a relationship of deep love, all the sharing that we discussed above are taken for granted. But love transcends (胜过) all this. During love, we are attached with a particular person, while in friendship, one may have many friends. A loving relationship makes one so much attached to the other, that one gets pained if his/her beloved is hurt! Love also involves a physical element. Friendship does not have that. This is a vital difference. Nature gives us love but does not give us friendship.

    Your heart beats will never increase in expectation of meeting your friend. You will not lie awake at night thinking about your friend. You will not feel totally lost, if you don't meet your friend for a few days. You will not have dreams in your eyes thinking about your friend. But in love, you will do all this and much more. Indeed, there is no comparison between love and friendship.

    Your next car might drive itself. After years of trials on city streets, driverless vehicles are now on the way. Last month, a driverless bus began carrying passengers through Lyon, France. Most in the automobile industry think self-driving vehicles will be on the road by 2020 or earlier.

    Driverless cars will first be huddled with human-driven cars. But the first places where they will become dominant（统治的）are highly populated urban areas. Many advanced cities are already reducing the role of human-driven cars. Driverless cars will quicken that process and will bring us enormous benefits.

    Driverless cars will reduce accidents by around 90 percent. That's big—the annual deaths on the world's roads are about 1.2 million a year. Pollution and carbon emissions will drop, because urban driverless cars will be electric.

    On the other hand, driverless cars will cause problems. Over the next 20 years, the mostly low-skilled men who now drive trucks, taxis and buses will see their jobs reduced. Traditional carmakers are especially scared. The cars of the future might be made by tech companies such as Apple, Baidu and Google. Imagine Germany, where automobile making is the largest industry.

    Dramatic changes are coming, and driverless cars could arrive by 2020. But governments have barely begun thinking about it. Only 6 percent of the biggest US cities have taken them into their long-term planning. A decade ago anyone hardly saw the Smartphone coming. Now what about the driverless cars?

    "Depend on yourself" is what nature says to everyone. Parents can help you. Teachers can help you. Others can help you. But all these only help you to help yourself.

    There have been many great men in history. But many of them were poor in childhood, and had no uncles, aunts or friends to help them. Schools were few and not very good. They could not depend on them for education. They saw how it was, and set to work with all their strength to know something. They worked their own way till they became well­known.

    One of the most famous teachers in England used to tell his pupils, "I can not make worthy men of you, but I can help you make men of yourselves."

    Some young men do not try their best to make themselves valuable to the human beings. They can never gain achievements unless they see their weak­points and change their courses. They are nothing now, and will be nothing as long as they live, unless they accept the advice of their parents and teachers, and depend on their own honest efforts.

     Aspirin has long been praised as a wonder drug. An aspirin a day keeps the doctor away. Many Americans have been taking one aspirin a day, believing it would protect them from a heart attack a stroke(中风), and even a cancer. But several recent studies have thrown this into question. Daily use of aspirin can have serious side effects(副作用).

    One study followed more than 19,000 healthy people aged 65 and older. They were required to take either 100 mg of aspirin (a little more than the 81 mg dose that most people take) or a placebo(无效对照剂) every day for about years, Not only did people in the aspirin group not lower their risk of heart disease, or disability but they were also more likely to suffer from bleeding into the brain or stomach. And they were more likely to die because of an increased risk of giving in to cancer, Similarly, an experiment of more than 12. 500 people aged 55 and older who have a cardiovascular (心血管的)risk found no benefit to taking aspirin daily. In study of more than 15,000 people with diabetes(糖尿病), a daily aspirin did prevent heart attacks and strokes, but it also caused serious bleeding.

    Although some earlier research has proved that aspirin can help people who have already had or are at high risk for heart attacks or strokes, the drug's value is not so clear for people, especially older people,

    The bottom line is this: Be smart and be safe. You should not take daily low-dose aspirin without talking to a doctor if you.

    ● Are over the age of 70

    ● Drink wine regularly

    ●Are on any simple medical operations

Spring and summer are the best seasons of the year for lots of activities, especially jogging (慢跑). This kind of running is the choice of many people who live in the city, work in the office and want to keep healthy. {#blank#}1{#/blank#}.

Make good preparations before jogging.

{#blank#}2{#/blank#}. There, you'll have an opportunity to find and buy all the necessary sportswear. Pay attention to the selection of jogging shoes, if you don't want to suffer from the feeling of heaviness, pain and leg swelling after the run. With all these pieces of wisdom; your body will be truly grateful to you.

Do fit warm-up activities.

Every runner, especially the beginner should know that all physical activities without a proper warm-up can cause a terrible pain and result in harm to muscles. It will probably lead to. final discomfort in your body oreven disease. {#blank#}3{#/blank#} Actually, it usually just takes you 15 minutes to increase the range of motion of ourjoints and warm up every muscle of the body.

{#blank#}4{#/blank#}.

When running, you usually feel physical and mental pleasure. Sometimes this pleasure can be replaced by negative feelings or even some kind of pain. No matter how healthy you're, you should always pay attention to how your body reacts. If something is wrong during your jog or run, the body will certainly let you know by giving you some hints (暗示). Watchfulness can help you avoid all possible after-effects of over exercise. Every type of sports is special and useful in its own way. While jogging can sometimes bring pain and discomfort, it really offers you greater joy and satisfaction. So don't step back. {#blank#}5{#/blank#} I hope these tips will help you prepare yourself for jogging and avoid some serious issues.

A. Listen to your body signals (信号).

B. Never give in to difficulties while jogging.

C. However, jogging without preparation will bring great harm.

D. One of the best ways to prepare is to go to specialized (专门的) shops.

E. Just go in for jogging, but remember to follow the above rules.

F. Therefore, you should make it a habit to warm up before jogging.

G. Here are some basic rules to make jogging safe, useful and comfortable.