Tu Youyou, 84, honored with the Nobel Prize in Physiology or Medicine on Oct 5, 2015. She was the first Chinese citizen to win a Nobel Prize in science for her work in helping to create an anti-malaria(疟疾) medicine. In 1967, Communist leader Mao Zedong decided there was an urgent national need to find a cure for malaria. At the time, malaria spread by mosquitoes was killing Chinese soldiers fighting Americans in the jungles of northern Vietnam. A secret research unit was formed to find a cure f or the illness. Tw o years later, Tu Youyou was instructed to become the new head of Mission 523. Researchers in Mission523 pored over ancient books to find historical methods of fighting malaria. When she started her search for an anti-malarial drug, over 240,000 compounds(化合物) around the world had already been tested, without any success.Finally, the team found a brief reference to one substance, sweet wormwood（青蒿）, which had been used to treat malaria in China around 400 AD. The team isolated one active compound in wormwood, artemisinin（青蒿素）, which appeared to battle malaria-friendly parasites（寄生虫）. The team then tested extracts（提取物） of the compound but nothing was effective until Tu Youyou returned to the original ancient text. After another careful reading, she improved the drug recipe one final time, heating the extract without allowing it to reach boiling point.

After the drug showed promising results in mice and monkeys, Tu volunteered to be the first human recipient of the new drug. “As the head of the research group, I had the responsibility.” she explained.

Why I've taken a break from holidays

    It is now close to four years since I last took a holiday. This is because I have come to the conclusion, over the course of my adult life, that I am not very good at it. You might think this sounds like saying you're not very good at drinking tea or listening to music. What could possibly be difficult about the natural act of putting your working life on hold for a couple of weeks and going somewhere warm to do nothing?

    I was a model holidaymaker as a kid. However, the problems started during my twenties. A trip to the south of France was ended after just two days, mainly because I had an urge to check my e-mails. Similarly, my honeymoon was cut short by 48 hours—not because my wife and I weren't enjoying ourselves, but because we were missing our cats.

    So what is my problem? On the surface, I'm probably a bit of a homebody. And I just find the pressure of being on holiday too severe: it always feels like having a gun held to my head and being forced to have fun. Somehow, packing a list of possessions and meeting a scheduled flight has none of the excitement of suddenly deciding to take a day off and driving somewhere for the fun of it.

    Thankfully, I'm not alone. This summer, most of my friends have decided not to have a break. And a recent survey (调查) proved the downside of holidays, with the results showing that nearly two thirds of people found that the calming effects of a holiday wore off within 24 hours, as stress levels returned to normal. And this year The Idler magazine published its Book of Awful Holidays. Here you will find a list of the five most ecologically-damaging vacations it's possible to take, along with 50 painful holiday experiences voted for on The Idler website.

    What interests me is what the concept of a “holiday” says about our lives. For me, the point of living is to have a life you enjoy for 52 weeks a year. The more I like my life and the better I structure it, the less I want to go away. Maybe I'm an unusual person for not liking holidays, but I just feel the time when I'm not working is too valuable to waste on them.

    A massive winter storm is expected to begin hitting Massachusetts tonight, dumping up to a foot or more of snow in some areas, while whipping the coast with powerful winds and driving rains, forecasters predict.

    “It's got a little bit of everything,” William Babecock, a meteologist（气象学家）at the National Weather Service in Taunton, said of the post-Christmas storm that brought snowstorm conditions to the Ohio Valley before heading east with its mixed bag of snow, sleet, and rain.

     State Highway Administrator Frank De Paola said more than 4,000 states and snowplows（扫雪车）and salt spreaders were ready to make the roads safer for holiday travelers.

    “MassDOT will be fully staffed and will be ready to handle this,” De Paola said, nothing that the storm, which should bring snow to most of the state except the Cape and Island before turning into rain tomorrow, is Massachusetts' first significant snow storm of this winter season.

    “There have been events where we have had pretty much freezing, icing concerns, which we have treated with chemicals.But this is the first big event that will call for plowing,” he said.

     A high wind watch has been issued for southeastern Massachusetts, including Cape Cod, Forecasters say the wind could reach 60 mph, possibly bringing down power lines.

    In Worcester, some were busy for severer by buying rock salt,shovels and windshield wash,Barrows Hardware president Brain Barrow said.He called the volume（总量）of customers at his Webster Street store very steady on Wednesday morning, “You do get that supermarket effect for sure,”he said of shoppers stocking supplies before a storm.

     There were no flight delays or cancellations at Logan International Airport in Boston as of day,” Right now, everything's running normally.” airport spokesman Richard Walsh said.But Walsh said as the day progressed, travelers should contact their airlines directly to check the status of their flights.

    Getting paid to stay in bed all day sounds pretty good. But what if someone offered you $23,000 to stay in bed for two months? That's the deal that are search team is offering to 24 volunteers.

    Researchers are looking for volunteers to help them study the influences of weightlessness on the human body by spending 60 days lying down. Lying in bed isn't exactly the same as being weightless, but the influences on the human body are similar.

    When astronauts spend a long time in an environment with no gravity(重力), like the International Space Station (ISS),their bodies are affected in many ways. After a couple of months on the ISS, astronauts' hearts don't beat as hard. Their muscles（肌肉）become weaker because they no longer have to work against gravity. Their bones may break more easily. There may also be changes in the astronauts' sleep habits.

    Dr. Arnaud Beck, the researcher in charge of the study, said his goal is to measure the influences of weightlessness, and also to find ways to prevent problems. The study will take 88 days altogether. During the first two weeks the volunteers will be tested to establish(确定) their levels of fitness. Then they will spend 60 days lying in bed with their heads slightly lower than their bodies. They will have to do everything while lying down, including brushing their teeth and going to the bathroom. Dr. Beck said the rule is that they must have at least one shoulder touching the bed at all times. Half of the volunteers in the study will be taking capsules(胶囊) containing special food supplements（增补物）several times a day to see if they help reduce the health problems caused by weightlessness. The last two weeks of the study will be spent trying to let the volunteers recover. Volunteers must be men between the ages of 20 and 45 who are in perfect health. They must be non-smokers.

    The study will take place from September 1^st to November. The first two days are the time for volunteers to sign in.

    A young woman sits alone in a café sipping tea and reading a book. She pauses briefly to write in a nearby notepad before showing her words to a passing café waiter: "Where are the toilets please?" This is a familiar scene in Tokyo's so-called "silent cafés", where customers are not allowed to speak, and only communicate by writing in notepads.

    The concept rises by a desire to be alone among young Japanese, a situation brought by economic uncertainty, a shift in traditional family support structures and the growing social isolation. The phenomenon is not limited to coffee shops but covers everything from silent discos, where participants dance alone wearing wireless headphones connected to the DJ, to products such as small desk tents designed for conversation-free privacy in the office. One Kyoto company even offers single women the opportunity to have a "one woman wedding"—a full bridal affair, complete with white dress and ceremony, and the only thing missing is the groom. The trend has its own media expression-“botchi-zoku”, referring to individuals who consciously choose to do things completely on their own.

    One recent weekday afternoon, Chihiro Higashikokubaru, a 23-year-old nurse, travelled 90 minutes from her home, to Tokyo on her day off in order to enjoy some solo time. Speaking quietly at the entrance of the cafe, Miss Higashikokubaru said: “I heard about this place via Twitter and I like the idea of coming here. I work as a nurse and it's always very busy. There are very few quiet places in Tokyo, and it's a big busy city. I just want to come and sit somewhere quietly on my own. I'm going to drink a cup of tea and maybe do some drawings. I like the idea of a quiet, calm atmosphere.”

    The desire to be isolated is not a new concept in Japan, home to an estimated 3.6 million "hikikomori" - a more extreme example of social recluses(隐士) who withdraw completely from society.

    I live in the center of the city and there is a largeparking lot full of parking spots nearby. Rain is a rare occurrence in LA,so cars easilycollect pollutants and dust. Together with my friends,I decided it shouldbe a kind gesture to surprise the owners with a car wash.So we bought carwashing supplies and brought out all the bath towels we could find.With all the suppliesin hand, wewere able to convince another roommate to help out as well and we beganwatering down the cars.

    Every once in a while, someone would come by and asked usseemingly stupid men, "Who told you to wash the cars?" or, even better, "who paid you to wash their cars?" Weexplained we just wanted to do something kind. But our response was often me with aneven more confused look.

    As the afternoon went on, some other friends that came byunderstood our goal of the spontaneous event and started helping out with someof the duties. Firstone friend then two, and by the time we had cleaned the entire lot,we had an entire carwashing crew with independent individually assigned tasks and duties.

    I wasn't cleaning cars to be able to afford a new phone.I was cleaning carssimply because I wanted to offer the car owners kindness.There was noequipment to weigh our value created. We couldn't measure our success indollars earned over the time spent washing cars when we could have been earningtwice as much at work.

    I now realize, first hand, that there is a special energy createdwhen you choose to think bigger than yourself and act in service of others andmaybe, likeme, you'llfind it's actually the greatest gift you' you'll ever get.