"Over the years the unthinkable hasbecome thinkable and today we sense we are close to being able to alter humanheredity œ#)." These were the words of David Baltimore of the CaliforniaInstitute of Technology, on December 1st, when he opened a three-day meeting inWashington to discuss the morality and use of human gene editing. Dr Baltimoreis an old hand at these sorts of discussions, for he was also a participant inthe Asilomar conference, in 1975, which brought scientists together to discussa safe way of using the then-new tcchnology of recombinant DNA, and whoserecommendations influenced a generation of biotechnology researchers.

Four decades on, the need for a similarsort of chin-wag has arisen. The InternationalSummit on Human Gene Editing has been held by the national scientific academiesof three countries — America, Britain and China. They are particularlyconcerned about whether gene editing should be used to make heritable changesto the human germ line, something Dr Baltimore described as a deep andtroubling question. Like those of Asilomar, the conclusions of this meetingwill not be binding. But the hope is that, again like Asilomar, a mixture ofcommon sense and peer pressure will create a world in which scientists aretrusted to regulate themselves, rather than having politicians and civilservants do it for them. The meeting is being held against a backdrop of rapidscientific advance, Since 2012 research into a new, easy-to-use editing tool calledCRISPR-Cas9 has blossomed. This technique involves a piece of RNA (a chemicalmessenger, which can be used to recognise a target section of DNA) and anenzyme (酶)called a nuclease that can snip unwanted genes out and paste new ones in.

Public interest was aroused in April,when Chinese scientists announced they had edited genes in non-viable ( 无活力的) humanembryos, and again in November when British researchers said they hadsuccessfully treated a one-year-old girl who had leukaemia ( 白血病),using gene-edited T-cells. T-cells are part of the immune system that attack,among other things, tumour cells. The researchers altered T-cells from ahealthy donor to encourage them to recognise and kill the patient's cancer, tomake them immune to her leukaemia drug, and to ensure they did not attack herhealthy cells.

In another recent development, a firmcalled Edit as Medicine, which is based in Cambridge, Massachusetts, has saidit hopes, in 2017, to start human clinical trials of CRISPR-Cas9 as a treatmentfor a rare genetic form of blindness known as Leber congenital amaurosis (伯氏先天性黑蒙).Though other companies are already testing gene-editing therapies, these employolder, clunkier forms of the technology that seem likely to have lesscommercial potential. Moreover, researchers at the Broad Institute, also inCambridge, said this week that they had made changes to CRISPR-Cas9 whichgreatly reduce the rate of editing errors — one of the main obstacles to thetechnique's medical use.

On the subject of germ-line editing,Eric Lander, the Broad's head, told the meeting it would be useful only in rarecases and said it might be a good idea to "exercise caution? before makingpermanent changes to the gene pool. The need for caution is advice that mightalso be heeded by those pursuing work in animals other than people, and inplants — subjects not being covered by the summit.

    “A good book might clarify something you knew little about, transform your world view, or move you in ways you didn't think possible. The Soul of an Octopus(章鱼)delivers on all three, ”the magazine New Scientist commented.

    After writing about birds, pigs and tigers, US naturalist Sy Montgomery decided to choose these many-footed animals as the subject of her latest book, The Soul of an Octopus: a surprising exploration into the wonder of consciousness.

    “Here is animal with poisonous liquid like a snake，a beak(喙)like a parrot，and ink like an old-fashioned pen. It can weigh as much as a man and extend as long as a car, yet it can pour its baggy; boneless body through an opening the size of all orange. It can change color and shape. It has a tongue covered with teeth. It can taste with its skin.” Montgomery explained to the National Geographic on why octopuses inspired her.

    What Montgomery is able to show in The Soul of an Octopus is that octopuses are creatures who exhibit personality, intelligence and emotion, despite having nervous systems completely different from our own. She uses different experiments to show that they possess consciousness as well as individual personalities. For example, based on her research, she finds out that Octavia, an octopus caught in the wild, is friendly and good at multi-tasking. And Kali, another octopus，who has been living at the New England Aquarium, is playful and loves exploring.

    Montgomery is a good storyteller. Through her study of, and communication with, these extraordinary creatures she shares what she learns from both science and her experiences. Her skillful writing presents facts together with personal description, which makes the book very informative but easy to read.

    It's rare that the protagonist in a Chinese movie wins the audience's hearts with an emotionally uplifting message, rather than by showing off his or her good looks. But Wolf Warrior II is putting China in the global spotlight. It's also the first film to taste success both in terms of box office earnings and promoting Chinese values.

    Kung fu artist Wu Jing both starred in and directed the action movie. Since its release on July 27, it's earned an unimaginable 4.5 billion yuan, setting a record for domestic movies at the box office. The success of the film has surpassed the anticipations of all, including the production team.

    The film focuses on a rescue operation in Africa, led by former special forces soldier Leng Feng-played by Wu. Leng helps Chinese workers and local Africans flee a war-torn and plague-ravaged country. Wolf Warrior II links art to reality, and reminds people of the massive evacuation of Chinese people from Libya when civil war broke out there in 2011, and from Yemen in 2015, as well as the challenges the Ebola virus created in West Africa from 2013 to 2016. The film describes how the Chinese government aims to protect overseas Chinese citizens. Just as the message at the end of the film reads: “Citizens of the People's Republic of China. When you encounter danger in a foreign land, do not give up! Please remember, at your back stands a strong motherland.”

    Thanks to China's increasing participation in global affairs, now could be considered the right moment to introduce a modern Chinese hero.

    “Holding up a banner of peace, friendship and responsibility, Wolf Warrior II should be seen as a brave effort to promote Chinese values around the world,” columnist Zhu Ping wrote in China Daily.

    “It's time Chinese filmmakers produced films that tell good stories and carry the right spirit. Let us assume Wolf Warrior II has started that trend.”

    I remember the day when I first learned to ride a bike. It was a frightening, yet fun experience. My granddad was the one who taught me, and he helped me when I got hurt. The first time I got on a bike, I had no idea what I was doing, and just about everything went wrong. My granddad told me to just put my feet on the pedals and start, pedaling(骑自行车). He also told me he would hold onto the back of the bike the whole time, yet he didn't.

    As soon as I started trying to balance myself, he let go. I happened to look back just then.  I was scared to death that I was going to fall and hurt myself. When I was scared, my mind went blank from pedaling, and I just wanted off. I forgot how to use the brakes(车闸) and fell right off the bike. My granddad kept encouraging me to get up and try again, and after about 15 minutes, I finally stopped crying, got up and tried again.

    As soon as I started pedaling again, my pants got caught in the chain, and I fell flat on my face and hit my nose. Since that happened, my granddad decided to call it a day and try again the next morning. The next morning I woke up bright and early, and was very eager to try to ride my bike. My nose felt better, so I wasn't that afraid of falling anymore.

    Though I knew there were a lot of difficulties on the way to mastering the skills in riding a bike, l believed I could do well with my granddad's help. After all, riding a bike was what I wanted to do eagerly.

    Tokyo is one of those places that you can love and hate at the same time.

    In Tokyo there are always too many people in the places where I want to be. Of course there are too many cars. The Japanese drive very fast, but in Tokyo they often spend a long time in traffic jams. Tokyo is not different from London, Paris and New York in that. It is different when one wants to walk.

    At certain times of the day there are a lot of people on foot in London's Oxford Street. But the streets near the Ginze in Tokyo always have a lot of people on foot， and sometimes it is really difficult to walk. People are very polite; there are just too many of them.

    The worst time to be in the street is at 11:30 at night. That is when the nightclubs are closing and everybody wants to go home. There are 35,000 nightclubs in Tokyo, and you do not often see one that is empty.

    During the day，most people travel to and from work by train. Tokyo people buy six million train tickets every day. At most stations, trains arrive every two or three minutes, but at certain hours there do not seem to be enough trains. Although they are usually crowded, Japanese trains are very good. They always leave and arrive on time. On a London train you would see everybody reading a newspaper. In Tokyo trains everybody in a seat seems to be asleep, whether his journey is long or short.

    In Tokyo, I stood outside the station for five minutes. Three fire-engines raced past on the way to one of the many fires that Tokyo has every day. Tokyo has so many surprises that none of them can really surprise me now.

    He is regarded as having one of the brightest minds on the planet. But outstanding astrophysicist (天体物理学家) Stephen Hawking has admitted that he did not learn to read until he was eight years old.

    In a public lecture at the Royal Albert Hall, Professor Hawking also admitted that he was not active in studying while at Oxford University, where he studied physics, and that only the diagnosis that he might die young from motor neurone (神经元) disease made him concentrate on his work.

    Professor Hawking said: "My sister Philippa could read by the age of 4 but then she was definitely brighter than me." He said that he was unexceptional at school and was never further than halfway up his class. "My classwork was very untidy, and my handwriting was the despair of my teachers," he said. "But my classmates gave me the nickname Einstein, so presumably they saw signs of something better."

    But he said that it was when doctors told him that he probably only had a few years to live at the age of 21 that galvanized him into focusing on his work and a period of productivity that resulted in some of his early breakthroughs. He said, "When you are faced with the possibility of an early death, it makes you realize that life is worth living and there are lots of things you want to do."